Acta Haematologica

Original Paper

Lymphocyte Subpopulations in Homozygous Sickle Cell Anaemia

Adedeji M.O.

Author affiliations

Department of Haematology, University of Benin Teaching Hospital, Benin City, Nigeria

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Acta Haematol 1985;74:10–13

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 28, 1985
Accepted: June 28, 1985
Published online: February 25, 2009
Issue release date: 1985

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA

Abstract

Patients with sickle cell disease have an increased tendency to develop frequent and severe pyo-genic infections. Lymphocyte subpopulations were studied in 14 patients with homozygous sickle cell anaemia (SCA) using the OKT monoclonal antibody. The mean absolute lymphocyte counts observed in patients with SCA were similar to that of controls. The OKT8+ lymphocytes were significantly higher in SCA patients than in controls. The mean OKT3+ and OKT4+ lymphocytes were significantly lower in SCA patients than in controls, and there is a reversal of the normal OKT4+: OKT8+ ratio. The number of B cells present, as detected by surface membrane immunoglobulin, was significantly higher in SCA patients when compared with control values. These preliminary findings suggest an important mechanism to further explain the increased tendency to infection in SCA patients, in addition to the previously described immunological disorders and the asplenic state

© 1985 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 28, 1985
Accepted: June 28, 1985
Published online: February 25, 2009
Issue release date: 1985

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


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