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Original Paper

Functional Changes in Marrow Stromal Cells in Aplastic Anaemia

Hotta T.a,b · Kato T.a · Maeda H.a · Yamao H.a · Yamada H.a · Saito H.a

Author affiliations

aFirst Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, and bSection of Haematology, Gifu College of Medical Technology, Gifu, Japan

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Acta Haematol 1985;74:65–69

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 05, 1985
Accepted: June 25, 1985
Published online: February 25, 2009
Issue release date: 1985

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA

Abstract

To determine whether or not abnormalities exist in the bone marrow stroma in aplastic anaemia, we analysed the ability of marrow stromal cells to support haemopoiesis using a long-term culture system. Marrow stromal cell layers from 3 of 9 patients with this disorder failed to maintain granulocyte-macrophage colony-forming cells in vitro. The stromal dysfunction was reversible in 1 patient who recovered after an-drogen therapy. The results of the present study add to the available evidence for a functional defect of marrow microenvironments in some cases of aplastic anaemia

© 1985 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 05, 1985
Accepted: June 25, 1985
Published online: February 25, 2009
Issue release date: 1985

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


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