Nephron Experimental Nephrology

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Retinoids and Renal Development

Burrow C.R.

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Mount Sinai School of Medicine, New York, N.Y., USA

Keywords: Renal developmentRetinoidsUreteric budMetanephrosc-retRetinoic acid receptorVitamin A deficiency syndromeNephronKidney

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Exp Nephrol 2000;8:219–225
https://doi.org/10.1159/000020672

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Article / Publication Details

First-Page Preview
Abstract of Minireview

Published online: July 31, 2000
Issue release date: July – October

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0


eISSN: 1660-2129 (Online)

For additional information: https://www.karger.com/NEE

Abstract

Although it has long been appreciated that retinoids play an essential role in kidney organogenesis, it has only recently been recognized that even mild fetal vitamin A deficiency syndromes can result in a reduction in nephron number. Recent studies have also begun to define the cellular and molecular events associated with retinoid actions in the fetal kidney and have demonstrated the essential function of retinoids in branching growth of the ureteric bud. Importantly, characterization of the renal developmental effects of RAR α/β2 double homozygous mice combined with metanephric organ culture studies have together shown that one essential function of retinoid action in the developing kidney is the maintenance of c-ret expression in the tips of the ureteric bud. However, many other potential retinoid target genes including midkine, sonic hedgehog, Hox d-11, matrix metalloproteinases, and tissue inhibitors of metalloproteinases appear to play important roles in renal development and might be important downstream mediators of retinoid effects in the developing kidney. It can, therefore, be anticipated that important new insights into fetal kidney development will be forthcoming in the near future, as the essential target genes affected by retinoid signal transduction are progressively elucidated.

© 2000 S. Karger AG, Basel



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References

  1. Burrow CR: Regulatory molecules in kidney development. Pediatr Nephrol, in press.
  2. Dressler GR: Genetic control of kidney development. Adv Nephrol Necker Hosp 1997; 26:1–17.
    External Resources
  3. Woolf AS: Clinical impact and biological basis of renal malformations. Semin Nephrol 1995; 15:361–371.
    External Resources
  4. Wilson JG, Warkany J: Malformations in the genito-urinary tract induced by maternal vitamin A deficiency in the rat. Am J Anat 1948;83:357–395.
  5. Wilson JG, Roth CB, Warkany J: An analysis of the syndrome of malformations induced by maternal vitamin A deficiency: Effects of restoration of vitamin A at various times during gestation. Am J Anat 1953;92:189–217.
    External Resources
  6. Merlet-Benichou C, Vilar J, Lelièvre-Pegorier M, Moreau E, Gilbert T: Fetal nephron mass: Its control and deficit. Adv Nephrol Necker Hosp 1997;26:19–45.
    External Resources
  7. Lelièvre-Pegorier M, Vilar J, Ferrier ML, Moreau E, Freund N, Gilbert T, Merlet-Benichou C: Mild vitamin A deficiency leads to inborn nephron deficit in the rat. Kidney Int 1998;54:1455–1462.
    External Resources
  8. Mendelsohn C, Batourina E, Fung S, Gilbert T, Dodd J: Stromal cells mediate retinoid-dependent functions essential for renal development. Development 1999; 126:1139–1148.
    External Resources
  9. Moreau E, Vilar J, Lelièvre-Pegorier M, Merlet-Benichou C, Gilbert T: Regulation of c-ret expression by retinoic acid in rat metanephros: Implication in nephron mass control. Am J Physiol 1998;275:F938–F945.
    External Resources
  10. Sainio K, Suvanto P, Davies J, Wartiovaara J, Wartiovaara K, Saarma M, Arumae U, Meng X, Lindahl M, Pachnis V, Sariola H: Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development 1997;124:4077–4087.
    External Resources
  11. Sanchez MP, Silos SI, Frisen J, He B, Lira SA, Barbacid M: Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 1996;382:70–73.
    External Resources
  12. Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, Sariola H, Westphal H: Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 1996; 382:73–76.
    External Resources
  13. Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, Sariola H, Westphal H: GDNF is required for kidney development and enteric innervation. Cold Spring Harb Symp Quant Biol 1996;61:445–457.
    External Resources
  14. Schuchardt A, D’Agati VD, Pachnis V, Costantini F: Renal agenesis and hypodysplasia in ret-k-mutant mice result from defects in ureteric bud development. Development 1996;122:1919–1929.
    External Resources
  15. Schuchardt A, D’Agati V, Larsson-Blomberg L, Costantini F, Pachnis V: Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 1994;367:380–383.
    External Resources
  16. McCollum EV, Davis M: The necessity of certain lipids during growth. J Biol Chem 1913;15:167–175.
  17. Karrer P, Morf R, Schoepp K: Zur Kenntnis des Vitamins A in Fischtranen. Helv Chim Acta 1931;14:1431–1436.
  18. Wald G: Molecular basis of visual excitation. Science 1968;162:230–239.
    External Resources
  19. Wolf G: A history of vitamin A and retinoids. FASEB J 1996;10:1102–1107.
    External Resources
  20. Fassi A, Sangalli F, Maffi R, Colombi F, Mohamed EI, Brenner BM, Remuzzi G, Remuzzi A: Progressive glomerular injury in the MWF rat is predicted by inborn nephron deficit. J Am Soc Nephrol 1998;9:1399–1406.
    External Resources
  21. Mackenzie HS, Lawler EV, Brenner BM: Congenital oligonephropathy: The fetal flaw in essential hypertension? Kidney Int 1996;55(suppl):30–34.
  22. Mackenzie HS, Brenner BM: Fewer nephrons at birth: A missing link in the etiology of essential hypertension? Am J Kidney Dis 1995;26:91–98.
    External Resources
  23. Merlet-Benichou C, Gilbert T, Vilar J, Moreau E, Freund N, Lelièvre-Pegorier M: Nephron number: Variability is the rule. Lab Invest 1999;79:515–527.
    External Resources
  24. Perneger TV, Whelton PK, Klag MJ: Race and end-stage renal disease: Socioeconomic status and access to health care as mediating factors. Arch Intern Med 1995;155:1201–1208.
    External Resources
  25. Underwood BA, Arthur P: The contribution of vitamin A to public health. FASEB J 1996;10:1040–1048.
    External Resources
  26. Gorodischer R, Sarov B, Gazala E, Hershkovitz E, Edwardson S, Sklan D, Katz M: Differences in cord serum retinol concentrations by ethnic origin in the Negev (southern Israel). Early Hum Dev 1995;42:123–130.
    External Resources
  27. Gebre-Medhin M, Vahlquist A: Vitamin A nutrition in the human foetus: A comparison of Sweden and Ethiopia. Acta Paediatr Scand 1984;73:333–340.
    External Resources
  28. Mitchell GV, Young M, Seward CR: Vitamin A and carotene levels of a selected population in metropolitan Washington, D.C. Am J Clin Nutr 1973;26:992–997.
    External Resources
  29. Butte NF, Calloway DH, Van Duzen JL: Nutritional assessment of pregnant and lactating Navajo women. Am J Clin Nutr 1981;34:2216–2228.
    External Resources
  30. Montreewasuwat N, Olson JA: Serum and liver concentrations of vitamin A in Thai fetuses as a function of gestational age. Am J Clin Nutr 1979;32:601–606.
    External Resources
  31. Shah RS, Rajalakshmi R: Vitamin A status of the newborn in relation to gestational age, body weight, and maternal nutritional status. Am J Clin Nutr 1984;40:794–800.
    External Resources
  32. Shah RS, Rajalakshmi R, Bhatt RV, Hazra MN, Patel BC, Swamy NB, Patel TV: Liver stores of vitamin A in human fetuses in relation to gestational age, fetal size and maternal nutritional status. Br J Nutr 1987;58:181–189.
    External Resources
  33. West KP Jr, Katz J, Khatry SK, LeClerq SC, Pradhan EK, Shrestha SR, Connor PB, Dali SM, Christian P, Pokhrel RP, Sommer A: Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group [see comments]. Br Med J 1999;318:570–575.
  34. Chambon P: A decade of molecular biology of retinoic acid receptors. FASEB J 1996;10:940–954.
    External Resources
  35. Minucci S, Ozato K: Retinoid receptors in transcriptional regulation. Curr Opin Genet Dev 1996;6:567–574.
    External Resources
  36. Napoli JL: Retinoic acid biosynthesis and metabolism. FASEB J 1996;10:993–1001.
    External Resources
  37. Bhat PV, Marcinkiewicz M, Li Y, Mader S: Changing patterns of renal retinal dehydrogenase expression parallel nephron development in the rat. J Histochem Cytochem 1998;46:1025–1032.
    External Resources
  38. Colbert MC, Linney E, LaMantia AS: Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development. Proc Natl Acad Sci USA 1993;90:6572–6576.
    External Resources
  39. Kastner P, Messaddeq N, Mark M, Wendling O, Grondona JM, Ward S, Ghyselinck N, Chambon P: Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes. Development 1997;124:4749–4758.
    External Resources
  40. Rossant J, Zirngibl R, Cado D, Shago M, Giguere V: Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev 1991;5:1333–1344.
    External Resources
  41. Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M, Chambon P: High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci USA 1993;90:7225–7229.
    External Resources
  42. Mendelsohn C, Mark M, Dolle P, Dierich A, Gaub MP, Krust A, Lampron C, Chambon P: Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal. Dev Biol 1994;166:246–258.
    External Resources
  43. Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P: Function of retinoic acid receptor gamma in the mouse. Cell 1993;73:643–658.
    External Resources
  44. Mendelsohn C, Lohnes D, Decimo D, Lufkin T, LeMeur M, Chambon P, Mark M: Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 1994;120:2749–2771.
    External Resources
  45. Weller A, Sorokin L, Illgen E-M, Ekblom P: Development and growth of mouse embryonic kidney in organ culture and modulation of development by soluble growth factor. Dev Biol 1991;144:248–261.
    External Resources
  46. Vilar J, Gilbert T, Morea E, Merlet-Benichou C: Metanephros organogenesis is highly stimulated by vitamin A derivatives in organ culture. Kidney Int 1996;49:1478–1487.
    External Resources
  47. Enokido Y, de Sauvage F, Hongo JA, Ninkina N, Rosenthal A, Buchman VL, Davies AM: GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin [in process citation]. Curr Biol 1998;8:1019–1022.
    External Resources
  48. Kotzbauer PT, Lampe PA, Heuckeroth RO, Golden JP, Creedon DJ, Johnson EM, Milbrandt J: Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 1996;384:467–470.
    External Resources
  49. Hatini V, Huh SO, Herzlinger D, Soares VC, Lai E: Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of winged Helix transcription factor BF-2. Genes and Develop 1996;10:1467–1478.
    External Resources
  50. Hyink DP, Burrow CR, Wilson PD: Retinoic acid and midkine induce epithelial conversion of renal progenitor cells associated with alterations in MMP secretion (abstract). J Am Soc Nephrol 1998;9:362.
  51. Patterson LT, Potter SS: Regulation of branching morphogenesis and patterning of the kidney during development (abstract). J Am Soc Nephrol 1998;9:366.
  52. Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR: Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 1995;375:791–795.
    External Resources
  53. Wood HB, Ward SJ, Moriss-Kay GM: Effects of all-trans-retinoic acid on skeletal pattern, 5’HoxD gene expression, and RAR beta 2/beta 4 promoter activity in embryonic mouse limbs. Dev Genet 1996;19:74–84.
    External Resources
  54. Mitsiadis TA, Salmivirta M, Muramatsu T, Muramatsu H, Rauvala H, Lehtonen E, Jalkanen M, Thesleff I: Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis. Development 1995;121:37–51.
    External Resources
  55. Ratovitski EA, Kotzbauer PT, Milbrandt J, Lowenstein CJ, Burrow CR: Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with Jak tyrosine kinases. J Biol Chem 1998;273:3654–3660.
    External Resources
  56. Kojima S, Muramatsu H, Amanuma H, Muramatsu T: Midkine enhances fibrinolytic activity of bovine endothelial cells. J Biol Chem 1995;270:9590–9596.
    External Resources
  57. Michikawa M, Xu RY, Muramatsu H, Muramatsu T, Kim SU: Midkine is a mediator of retinoic acid induced neuronal differentiation of embryonal carcinoma cells. Biochem Biophys Res Commun 1993;192:1312–1318.
    External Resources
  58. Pedraza C, Matsubara S, Muramatsu T: A retinoic acid-responsive element in human midkine gene. J Biochem (Tokyo) 1995;117:845–849.
    External Resources
  59. Tienari J, Pertovaara L, Saksela O, Lehtonen E, Vartio T: Increased expression of the matrix metalloproteinase 2 in differentiating Tera 2 human embryonal carcinoma cells. Int J Cancer 1994;56:219–223.
    External Resources
  60. Nicholson RC, Mader S, Nagpal S, Leid M, Rochette-Egly C, Chambon P: Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J 1990;9:4443–4454.
    External Resources
  61. Kojima S, Rifkin DB: Mechanism of retinoid-induced activation of latent transforming growth factor-beta in bovine endothelial cells. J Cell Physiol 1993;155:323–332.
    External Resources
  62. Kratzschmar J, Haendler B, Kojima S, Rifkin DB, Schleuning WD: Bovine urokinase-type plasminogen activator and its receptor: Cloning and induction by retinoic acid. Gene 1993;125:177–183.
    External Resources
  63. Braunhut SJ, Moses MA: Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP). J Biol Chem 1994;269:13472–13479.
    External Resources
  64. Lelongt B, Trugnan G, Murphy G, Ronco PM: Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro. J Cell Biol 1997;136:1363–1373.
    External Resources
  65. Barasch J, Yang J, Qiao J, Tempst P, Erdjument-Bromage H, Leung W, Oliver JA: Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros. J Clin Invest 1999;103:1299–1307.
    External Resources
  66. Lohnes D, Mark M, Mendelsohn C, Dolle P, Dierich A, Gorry P, Chambon P: Function of the retinoic acid receptors (RARs) during development. Development 1994;120:2723–2748.
    External Resources
  67. Motoyama J, Liu J, Mo R, Ding Q, Post M, Hui CC: Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus (see comments). Nat Genet 1998;20:54–57.
    External Resources
  68. Litingtung Y, Lei L, Westphal H, Chiang C: Sonic hedgehog is essential to foregut development (see comments). Nat Genet 1998; 20:58–61.
    External Resources
  69. Whitsett J: A lungful of transcription factors. Nat Genet 1998;20:7–9.
    External Resources
  70. Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA: Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 1996;383:407–413.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Minireview

Published online: July 31, 2000
Issue release date: July – October

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0


eISSN: 1660-2129 (Online)

For additional information: https://www.karger.com/NEE

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2000, Vol.8, No. 4-5

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