Endocrine Involvement in Developmental Syndromes

Editor(s): Cappa, M. (Rome)
Maghnie, M. (Genova)
Loche, S. (Cagliari)
Bottazzo, G.F. (Roma)
 

Developmental Abnormalities of the Posterior Pituitary Gland

di Iorgi N. · Secco A. · Napoli F. · Calandra E. · Rossi A. · Maghnie M.

Author affiliations

Departments of Pediatrics and Neuroradiology (A.R.), IRCCS G, Gaslini Institute, University of Genova, Genova, Italy

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Cappa M, Maghnie M, Loche S, Bottazzo GF (eds): Endocrine Involvement in Developmental Syndromes. Endocr Dev. Basel, Karger, 2009, vol 14, pp 83–94

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: February 27, 2009
Cover Date: 2009

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9041-9 (Print)
eISBN: 978-3-8055-9042-6 (Online)

Abstract

While the molecular mechanisms of anterior pituitary development are now better understood than in the past, both in animals and in humans, little is known about the mechanisms regulating posterior pituitary development. The posterior pituitary gland is formed by the evagination of neural tissue from the floor of the third ventricle. It consists of the distal axons of the hypothalamic magnocellular neurones that shape the neurohypophysis. After its downward migration, it is encapsulated together with the ascending ectodermal cells of Rathke’s pouch which form the anterior pituitary. By the end of the first trimester, this development is completed and vasopressin and oxytocin can be detected in neurohypophyseal tissue. Abnormal posterior pituitary migration such as the ectopic posterior pituitary lobe appearing at the level of median eminence or along the pituitary stalk have been reported in idiopathic GH deficiency or in subjects with HESX1, LHX4 and SOX3 gene mutations. Another intriguing feature of abnormal posterior pituitary development involves genetic forms of posterior pituitary neurodegeneration that have been reported in autosomal-dominant central diabetes insipidus and Wolfram disease. Defining the phenotype of the posterior pituitary gland can have significant clinical implications for management and counseling, as well as providing considerable insight into normal and abnormal mechanisms of posterior pituitary development in humans.

© 2009 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: February 27, 2009
Cover Date: 2009

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9041-9 (Print)
eISBN: 978-3-8055-9042-6 (Online)


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