Functional MRI and Response Inhibition in Children Exposed to Cocaine in utero
Sheinkopf S.J.a · Lester B.M.a, b · Sanes J.N.c · Eliassen J.C.c · Hutchison E.R.c · Seifer R.a · LaGasse L.L.b · Durston S.d, e · Casey B.J.d
Departments of aPsychiatry and Human Behavior and bPediatrics, Warren Alpert Medical School of Brown University, cDepartment of Neuroscience, Brown University, Providence, R.I., and dThe Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, N.Y., USA; eDepartment of Child and Adolescent Psychiatry, The University Medical Center Utrecht, Utrecht, The Netherlands
Stephen J. Sheinkopf, PhD
Brown Center for the Study of Children at Risk
Women and Infants Hospital of Rhode Island
101 Dudley Street, Providence, RI 02905 (USA)
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This study investigated the potential long-term effects of cocaine exposure on brain functioning using fMRI in school-aged children. The sample included 12 children with prenatal cocaine exposure and 12 non-exposed children (8–9 years old). Groups did not differ on IQ, socioeconomic status, or perinatal risk factors. A response inhibition task was administered during an fMRI scan using a 1.5-T MRI system. Task performance did not differentiate groups, but groups were differentiated by patterns of task-related brain activity. Cocaine-exposed children showed greater activation in the right inferior frontal cortex and caudate during response inhibition, whereas non-exposed children showed greater activations in temporal and occipital regions. These preliminary findings suggest that prenatal cocaine may affect the development of brain systems involved in the regulation of attention and response inhibition.
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