Acta Haematologica

 

Large Granules and Lysosomal Fusion in Human Chediak-Higashi White Blood Cells

Rozenszajn L.A. · David E.B. · Sela S.B.

Author affiliations

Hematologic Laboratories, Meir Hospital, Kfar Saba and Department of Life Sciences, Bar-Ilan University, Ramat-Gan

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Acta Haematol 1977;57:279–289

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 03, 2009
Issue release date: 1977

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA

Abstract

The phenomenon of giant anomalous lysosome formation in human Chediak-Higashi syndrome leukocytes was analyzed. Ultrastructure findings combined with cytochemical procedures for visualizing acid phosphatase and peroxidase activity showed giant anomalous granules in addition to normal, small and enlarged granules. Massive granules in lymphocytes had an appearance and structure different from those found in other leukocytes. The giant granules seem to be a product of an active fusion between primary and secondary normal sized or enlarged lysosomes. This fusion occurs in polymorphonuclear neutrophils, eosinophils and in monocytes. No fusion was found in lymphocyte granules.

© 1977 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 03, 2009
Issue release date: 1977

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


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