Kidney and Blood Pressure Research
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Serum Neutrophil Gelatinase-Associated Lipocalin as a Marker of Renal Function in Patients with Chronic Heart Failure and Coronary Artery DiseasePoniatowski B.a · Malyszko J.b · Bachorzewska-Gajewska H.a · Malyszko J.S.b · Dobrzycki S.aDepartments of aInvasive Cardiology, and Hypertension, and bNephrology, Medical University, Bialystok, Poland
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Article / Publication Details
Received: August 28, 2008
Accepted: January 09, 2009
Published online: March 14, 2009
Issue release date: June 2009
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)
For additional information: https://www.karger.com/KBR
Abstract
Heart failure and chronic kidney disease share a number of risk factors and pathophysiological pathways. Renal insufficiency is common in patients with chronic heart failure (CHF). The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) could represent a novel, sensitive marker of kidney function in adult patients with chronic heart failure and normal serum creatinine. The study was performed on 150 patients with chronic heart failure due to coronary artery disease. Serum and urinary NGAL as well as serum cystatin C were measured using commercially available kits. Serum NGAL was related, in univariate analysis, to serum creatinine, urinary NGAL, hemoglobin, hematocrit, leukocyte count, eGFR, cystatin C. Urinary NGAL correlated with age, hemoglobin, hematocrit, serum creatinine, eGFR. In multiple regression analysis predictors of serum NGAL were NYHA class, cystatin C, and eGFR. Taking into consideration the fact that the recent DOQI states that individuals with a reduced GFR is at greater risk for cardiovascular disease and cardiac deaths, precise evaluation of renal function is important in order to select the appropriate strategy to reduce the cardiovascular risk. NGAL should be investigated as a potential early and sensitive marker of kidney impairment/injury.
© 2009 S. Karger AG, Basel
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Article / Publication Details
Received: August 28, 2008
Accepted: January 09, 2009
Published online: March 14, 2009
Issue release date: June 2009
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)
For additional information: https://www.karger.com/KBR
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