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Original Research Article

Free Access

Agreement in Cognitive and Clinical Assessments in Alzheimer’s Disease

Tractenberg R.E.a, b · Aisen P.S.b

Author affiliations

aDepartments of Neurology, Biostatistics, Bioinformatics and Biomathematics, and Psychiatry, Georgetown University School of Medicine, Washington, D.C., and bDepartment of Neurology, University of California, San Diego, La Jolla, Calif., USA

Corresponding Author

Rochelle E. Tractenberg

Georgetown University School of Medicine

Collaborative for Research on Outcomes and -Metrics

Building D, Suite 207, 4000 Reservoir Rd. NW, Washington, DC 20057 (USA)

Tel. +1 202 444 8748, Fax +1 202 444 4114, E-Mail ret7@georgetown.edu

Related Articles for ""

Dement Geriatr Cogn Disord 2009;27:344–352

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Aims: To estimate agreement among scores on three common assessments of cognitive function. Method: Baseline responses on the Alzheimer’s Disease Assessment Scale – Cognitive, Clinical Dementia Rating, and the Mini-Mental State Examination were obtained from two clinical trials (n = 138 and n = 351). A graphical method of examining agreement, the means-difference or Bland-Altman plot, was followed by Levene’s test of the equality of variance corrected for multiple comparison within each sample. Results: 70–78% of variability was shared by one factor, suggesting that all three instruments reflect cognitive impairment. However, agreement among tests was significantly worse for individuals with greater-than-average, relative to individuals with less-than-average, cognitive impairment. Conclusions: Worse agreement between tests, as a function of increasing cognitive impairment, implies that interpretation of these tests and selection of coprimary cognitive impairment outcomes may depend on impairment level.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: October 20, 2008
Published online: March 17, 2009
Issue release date: April 2009

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

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