Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Multifocality Incidence and Accompanying Clinicopathological Factors in Renal Cell Carcinoma

Sargin S.Y. · Ekmekcioglu O. · Arpali E. · Altinel M. · Voyvoda B.

Author affiliations

Department of Urology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey

Related Articles for ""

Urol Int 2009;82:324–329

Do you have an account?

Login Information





Contact Information











I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information











I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 08, 2007
Accepted: January 01, 2008
Published online: May 11, 2009
Issue release date: May 2009

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: https://www.karger.com/UIN

Abstract

Introduction: The incidence of multifocality and associated clinicopathological factors in renal cell carcinoma were evaluated. Materials and Methods: Clinicopathological characteristics were assessed for 122 renal cell carcinoma-pathological specimens from 121 patients. Microscopic and gross tumor pathology, incidence of multifocality as well as association between tumor grade, histological subtype, stage, size and vascular involvement were assessed. Results: Multifocal renal cell carcinoma was diagnosed in 16 of 122 specimens (13.1%). Satellite lesions for 15 of 16 specimens displaying mulifocality had the same histological subtype as their primary tumor. The occult multifocality rate was 11.4%. Tumor grade and stage, but not size or volume, histological subtype, and vascular involvement were significantly related to multifocality. Conclusions: Accurate staging of renal cell carcinoma appears to be essential in determining whether a patient should undergo nephron-sparing surgery or radical nephrectomy. Patients with high stage and grade should receive the highest attention after nephron-sparing surgery. Larger studies are needed to further elucidate the association between clinicopathological factors and multifocality.

© 2009 S. Karger AG, Basel


References

  1. Whang M, O’Toole K, Bixon R, Brunetti J, Ikeguchi E, Olsson CA, Sawczuk TS, Benson MC: The incidence of multifocal renal cell carcinoma in patients who are candidates for partial nephrectomy. J Urol 1995;154:968–971.
  2. Gohji K, Hara I, Gotoh A, Eto H, Miyake H, Sugiyama T, Okada H, Arakawa S, Kamidono S: Multifocal renal cell carcinoma in Japanese patients with tumors with maximal diameters of 50 mm or less. J Urol 1998;159:1144–1147.
  3. Kletscher BA, Qian J, Bostwick DG, Andrews PE, Zincke H: Prospective analysis of multifocality in renal cell carcinoma: influence of histological pattern, grade, number, size, volume and deoxyribonucleic acid ploidy. J Urol 1995;153:904–906.
  4. Baltacı S, Orhan D, Soyupek S, Bedük Y, Tulunay O, Göğüş O: Influence of tumor stage, size, grade, vascular involvement, histological cell type and histological pattern on multifocality of renal cell carcinoma. J Urol 2000;164:36–39.
  5. Richstone L, Scherr DS, Reuter VR, Snyder ME, Rabbani F, Kattan MW, Russo P: Multifocal renal cortical tumors: frequency, associated clinicopathological features and impact on survival. J Urol 2004;171:615–620.
  6. Melissourgos N, Doumas K, Messim I, Papaliodi E, Kastrinakis NG, Lykourinas M: Multicentricity in renal cell carcinoma: can primary tumor location serve as a co-determinant of surgical treatment? Eur Urol 2002;41:262–266.
  7. Li QL, Guan HW, Zhang QP, Xue J, Wang FP, Song XS: Multifocality and its associated factors in renal cell carcinoma. Chin Med J 2002;115:1341–1344.
  8. Di Marco DS, Lohse CM, Zinche H, Cheville JC, Blute ML: Long-term survival of patients with unilateral sporadic multifocal renal cell carcinoma according to histologic subtype compared with patients with solitary tumors after radical nephrectomy. Urology 2004;64:462–467.
  9. Fuhrman SA, Lasky LC, Limas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6:655–663.
  10. Störkel S, Eble JN, Adlakha K, Amin M, Blute ML, Bostwick DG, Darson M, Delahunt B, Iczkowski K: Classification of renal cell carcinoma. Cancer 1997;80:987–989.
  11. Sobin LH, Wittekind C: TNM Classification of Malignant Tumors, ed 6. New York, Wiley-Liss, 2002, p 239.
  12. Karayiannis A, Varkarakis I, Chort M, Alivizatos G, Fragiskos S: Multifocality of renal cell tumors is a factor to consider before performing a partial nephrectomy. Anticancer Res 2002;22:3103–3107.
  13. Lang H, Lindner V, Martin M, Letourneux H, Roy C, Saussine C, Jacqmin D: Prognostic value of multifocality on progression and survival in localized renal cell carcinoma. Eur Urol 2004;45:749–753.
  14. Oya M, Nakamura K, Baba S, Hata JI, Tazaki H: Intrarenal satellites of renal cell carcinoma: histopathologic manifestation and clinical implication. Urology 1995;46:161–164.
  15. Kinouchi T, Mano M, Saiki S, Meguro N, Maeda O, Kuroda M, Usami M, Kotake T: Incidence rate of satellite tumors in renal cell carcinoma. Cancer 1999;86:2331–2336.
  16. Mejean A, Hopirtean V, Bazin JP, Larousserie F, Benoit H, Chretien Y, Thiounn N, Dufour B: Prognostic factors for the survival of patients with papillary renal cell carcinoma: meaning of histological typing and multifocality. J Urol 2003;170:764–767.
  17. Uzzo RG, Novick AC: Nephron sparing surgery for renal tumors: indications, techniques and outcomes. J Urol 2001;166:6–18.
  18. Bilen CY, Mahalati K, Ozen H, Aki TF, Ilyas C, Kendi S: Multicentricity in renal cell carcinoma. Int Urol Nephrol 1999;31:295–299.
  19. Schlichter A, Schubert R, Werner W, Zermann DH, Schubert J: How accurate is diagnostic imaging in determination of size and multifocality of renal cell carcinoma as a prerequisite for nephron sparing surgery? Urol Int 2000;64:192–197.
  20. Kopka L, Fischer U, Zoeller G, Schmidt C, Ringert RH, Grabbe E: Dual-phase helical CT of the kidney: value of the corticomedullary and nephrographic phase for evaluation of renal lesions and preoperative staging of renal cell carcinoma. Am J Roentgenol 1997;169:1573–1578.
  21. Huang JG, Israel G, Berman A, Taneja SS: Preoperative renal tumor evaluation by three-dimensional magnetic resonance imaging: staging and detection of multifocality. Urology 2004;64:453–457.
  22. Remzi M, Özsoy M, Klingler HC, Susani M, Waldert M, Seitz C, Schmidbauer J, Marberger M: Are small renal tumors harmless? Analysis of histopathological features according to tumors 4 cm or less in diameter. J Urol 2006;176:896–899.
  23. Wunderlich H, Schlichter A, Zermann DH, Reichelt O, Kosmehl H, Schubert J: Multifocality in renal cell carcinoma: a bilateral event? Urol Int 1999;63:160–163.
  24. Wunderlich H, Reichelt O, Schuman S, Schlichter A, Kosmehl H, Wener W, Vollandt R, Schubert J: Nephron sparing surgery for renal cell carcinoma 4 cm or less in diameter: indicated or under treated? J Urol 1998;159:1465–1469.
  25. Lerner SE, Hawkins CA, Blute ML, Grabner A, Wollan PC, Eickholt JT, Zincke H: Disease outcome in patients with low stage renal cell carcinoma treated with nephron sparing or radical surgery. J Urol 1996;155:1868–1873.
  26. Hafez KS, Fergany AF, Novick AC: Nephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging. J Urol 1999;162:1930–1933.
  27. Fergany AF, Hafez KS, Novick AC: Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup. J Urol 2000;163:442–445.
  28. Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML: Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol 2003;27:612–624.
  29. Ghavamian R, Cheville JC, Lohse CM, Weaver AL, Zincke H, Blute ML: Renal cell carcinoma in the solitary kidney: an analysis of complications and outcome after nephron sparing surgery. J Urol 2002;168:454–459.
  30. Ljungberg B, Hanbury DC, Kuczyk MA, Merseburger AS, Mulders PFA, Patard JJ, Sinescu IC: Guidelines on Renal Cell Carcinoma. Arnhem, European Association of Urology, 2007, pp 4–13.
  31. Lee CT, Katz J, Shi W, Thaler HT, Reuter VE, Russo P: Surgical management of renal tumors 4 cm or less in a contemporary cohort. J Urol 2000;163:730–736.
  32. Blute ML, Thibault GP, Leibovich BC, Cheville JC, Lohse CM, Zincke H: Multiple ipsilateral renal tumors discovered at planned nephron sparing surgery: importance of tumor histology and risk of metachronous recurrence. J Urol 2003;170:760–763.
  33. Barbalias GA, Liatsikos EN, Tsintavis A, Nikiforidis G: Adenocarcinoma of the kidney: nephron sparing surgical approach vs. radical nephrectomy. J Surg Oncol 1999;72:156–161.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 08, 2007
Accepted: January 01, 2008
Published online: May 11, 2009
Issue release date: May 2009

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: https://www.karger.com/UIN


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.