Neonatology

Review

Free Access

Congenital Diaphragmatic Hernia: Comparison of Animal Models and Relevance to the Human Situation

van Loenhout R.B.a, b · Tibboel D.b · Post M.a · Keijzer R.a, b

Author affiliations

aProgram in Physiology and Experimental Medicine, Hospital for Sick Children, Toronto, Ont., Canada; bDepartment of Pediatric Surgery, Erasmus MC-Sophia, Rotterdam, The Netherlands

Corresponding Author

Richard Keijzer, MD, PhD, MSc

Erasmus MC-Sophia, Room SK-1254

Dr Molewaterplein 60

NL–3015 GJ Rotterdam (The Netherlands)

Tel. +31 10 704 6783, Fax +31 10 703 6802, E-Mail r.keijzer@erasmusmc.nl

Keywords: CDHPulmonary hypoplasiaTransgenicsNitrofenRetinoidsSurgery

Related Articles for ""
Neonatology 2009;96:137–149
https://doi.org/10.1159/000209850

Abstract

Congenital diaphragmatic hernia (CDH) occurs in 1 in 3,000 newborns. Mortality and morbidity are due to the amount of pulmonary hypoplasia (PH), the response on artificial ventilation and the presence of therapy-resistant pulmonary hypertension. The pathogenesis and etiology of CDH and its associated anomalies are still largely unknown despite all research efforts over the past years. Several animal models have been proposed to study CDH. In this review we compare surgical, pharmacological and transgenic models, and discuss their strengths and limitations to study PH.

© 2009 S. Karger AG, Basel



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