Association of a 5-HT1Dβ Receptor Gene Polymorphism with Obsessive-Compulsive Disorder in Korean Male SubjectsKim S.J.a · Namkoong K.a · Kang J.I.a, b · Kim C.-H.a
aDepartment of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University, College of Medicine, Seoul, and bDepartment of Psychiatry, Ilsan Hospital, National Health Insurance Corporation, Gyeonggi-do, Republic of Korea
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Article / Publication Details
The 5-HT1Dβ receptor gene appears to be particularly interesting in the pathophysiology of obsessive-compulsive disorder (OCD). The 5-HT1Dβ receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. We performed an association study of the G861C single nucleotide polymorphism (SNP) of the 5-HT1Dβ receptor in 167 male Korean OCD subjects and in 107 controls. Individuals with the G allele had an increased chance of having OCD (OR 1.49, 95% CI 1.05–2.10). Our findings suggest an association between the G861C SNP of the 5-HT1Dβ receptor and males with OCD. In the future, other tag SNPs that cover the entire 5-HT1Dβ gene region as well as additional SNPs that are supposed to have meaningful functions should be investigated in both male and female OCD subjects.
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