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Original Paper

Association of a 5-HT1Dβ Receptor Gene Polymorphism with Obsessive-Compulsive Disorder in Korean Male Subjects

Kim S.J.a · Namkoong K.a · Kang J.I.a, b · Kim C.-H.a

Author affiliations

aDepartment of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University, College of Medicine, Seoul, and bDepartment of Psychiatry, Ilsan Hospital, National Health Insurance Corporation, Gyeonggi-do, Republic of Korea

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Neuropsychobiology 2009;59:96–99

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 09, 2008
Accepted: February 01, 2009
Published online: March 27, 2009
Issue release date: May 2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

The 5-HT1Dβ receptor gene appears to be particularly interesting in the pathophysiology of obsessive-compulsive disorder (OCD). The 5-HT1Dβ receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. We performed an association study of the G861C single nucleotide polymorphism (SNP) of the 5-HT1Dβ receptor in 167 male Korean OCD subjects and in 107 controls. Individuals with the G allele had an increased chance of having OCD (OR 1.49, 95% CI 1.05–2.10). Our findings suggest an association between the G861C SNP of the 5-HT1Dβ receptor and males with OCD. In the future, other tag SNPs that cover the entire 5-HT1Dβ gene region as well as additional SNPs that are supposed to have meaningful functions should be investigated in both male and female OCD subjects.

© 2009 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 09, 2008
Accepted: February 01, 2009
Published online: March 27, 2009
Issue release date: May 2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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