Neonatology
Original Paper
Association of Interleukin-13/-4 and Toll-Like Receptor 10 with Preterm BirthsHeinzmann A. · Mailaparambil B. · Mingirulli N. · Krueger M.Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
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Article / Publication Details
Received: August 05, 2008
Accepted: October 10, 2008
Published online: March 31, 2009
Issue release date: September 2009
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Background: Preterm birth (PTB) is accompanied by an increased neonatal morbidity. The cause of PTB is multifactorial and the interplay between environmental and genetic factors – of mothers and newborns – determines the risk. Objectives: We were interested to identify fetal genes predisposing to PTB in the German population. Methods: We started our study by screening 31 polymorphisms within 15 genes of 121 preterm infants born below 32 gestational weeks and 270 healthy controls. Genotyping was performed by restriction fragment length polymorphism. Statistical analyses used Armitage’s trend test for single polymorphisms and FAMHAP for calculation of haplotypes. Results: No single polymorphism showed association with PTB; however, haplotypes of interleukin (IL)-13/IL-4 and Toll-like receptor (TLR)-10 were associated (p = 0.0001 and p = 0.0011, respectively). The association was further confirmed in an extended population of a total of 164 preterm infants. Furthermore, one polymorphism in IL-13 showed a weak association with PTB in this population (p = 0.031). Finally, we analyzed whether the cause of PTB, i.e. medically indicated cesarean section versus spontaneous PTB, affects association results and found evidence in favor of a separate analysis of both groups. Conclusions: IL-13/IL-4 and TLR-10 might be involved in the genetics of PTB. The dissection of the genetic background may provide a deeper understanding of the pathophysiology of PTB and help to identify new drug targets for its prevention.
© 2009 S. Karger AG, Basel
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References
-
Slattery MM, Morrison JJ: Preterm delivery. Lancet 2000;360:1489–1497.
External Resources
- Saigal S, Doyle LW: An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 2008;371:261–269.
- Ward K, Argyle V, Meade M, Nelson L: The heritability of preterm delivery. Obstet Gynecol 2005;106:1235–1239.
- Porter TF, Fraser AM, Hunter CY, Ward RH, Varner MW: The risk of preterm birth across generations. Obstet Gynecol 1997;90:63–67.
- Krediet TG, Wiertsema SP, Vossers MJ, Hoeks SB, Fleer A, Ruven HJ, Rijkers GT: Toll-like receptor-2 polymorphism is associated with preterm birth. Pediatr Res 2007;62:474–476.
- Lorenz E, Hallman M, Marttila R, Haataja R, Schwartz DA: Association between the Asp299Gly polymorphisms in the Toll-like receptor-4 and premature births in the Finnish population. Pediatr Res 2002;52:373–376.
- Aidoo M, McElroy PD, Kolczak MS, Terlouw DJ, ter Kuile FO, Nahlen B, Lal AA, Udhayakumar V: Tumor necrosis factor-α promoter variant 2 (TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort Project IX. Genet Epidemiol 2001;21:201–211.
- Härtel C, Finas D, Ahrens P, Kattner E, Schaible T, Müller D, Segerer H, Albrecht K, Möller J, Diedrich K, Göpel W; Genetic Factors in Neonatology Study Group: Polymorphisms of genes involved in innate immunity: association with preterm delivery. Mol Hum Reprod 2004;10:911–915.
- Kalish RB, Vardhana S, Gupta M, Perni SC, Witkin SS: Interleukin-4 and -10 gene polymorphisms and spontaneous preterm birth in multifetal gestations. Am J Obstet Gynecol 2004;190:702–706.
- Esplin MS: Preterm birth: a review of genetic factors and future directions for genetic study. Obstet Gynecol Surv 2006;61:800–806.
- Pennell CE, Jacobsson B, Williams SM, Buus RM, Muglia LJ, Dolan SM, Morken NH, Ozcelik H, Lye SJ; PREBIC Genetics Working Group, Relton C: Genetic epidemiologic studies of preterm birth: guidelines for research. Am J Obstet Gynecol 2007;196:107–118.
- Savitz DA, Dole N, Herring AH, Kaczor D, Murphy J, Siega-Riz AM, Thorp JM Jr, MacDonald TL: Should spontaneous and medically indicated preterm births be separated for studying aetiology? Paediatr Perinat Epidemiol 2005;19:97–105.
- Puthothu B, Krueger M, Forster J, Heinzmann A: Association between severe respiratory syncytial virus infection and IL- 13/IL-4 haplotypes. J Infect Dis 2006;193:438–441.
- Krueger M, Puthothu B, Heinze J, Forster J, Heinzmann A: Genetic polymorphisms of adhesion molecules in children with severe RSV-associated diseases. Int J Immunogenet 2006;33:233–235.
-
Puthothu B, Bierbaum S, Kopp MV, Forster J, Heinze J, Weckmann M, Krueger M, Heinzmann A: Association of TNF-α with severe respiratory syncytial virus RSV infection and asthma. Pediatr Allergy Immunol 2008, Sep 22 [epub ahead of print].
- Sanger F, Nicklen S, Coulson AR: DNA sequencing with chain-terminating inhibitors. 1977. Biotechnology 1992;24:104–108.
- Sasieni PD: From genotypes to genes: doubling the sample size. Biometrics 1997;53:1253–1261.
- Xu J, Turner A, Little J, Bleecker ER, Meyers DA: Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error? Hum Genet 2002;111:573–574.
- Becker T, Knapp M: Maximum-likelihood estimation of haplotype frequencies in nuclear families. Genet Epidemiol 2004;27:21–32.
- Han YM, Romero R, Kim YM, Kim JS, Richani K, Friel LA, Kusanovic JP, Jeanty C, Vitale S, Nien JK, Espinoza J, Kim CJ: Surfactant protein-A mRNA expression by human fetal membranes is increased in histological chorioamnionitis but not in spontaneous labour at term. J Pathol 2007;211:489–496.
-
Goldenberg RL, Andrews WW, Hauth JC: Choriodecidual infection and preterm birth. Nutr Rev 2002;60:19–25.
External Resources
- Haddad R, Romero R, Gould BR, Tromp G, Gotsch F, Edwin SS, Zingg HH: Angiogenesis gene expression in mouse uterus during the common pathway of parturition. Am J Obstet Gynecol 2008;198:539.e1–539.e8.
- Bányász I, Bokodi G, Vásárhelyi B, Treszl A, Derzbach L, Szabó A, Tulassay T, Vannay A: Genetic polymorphisms for vascular endothelial growth factor in perinatal complications. Eur Cytokine Netw 2006;17:266–270.
- Aliefendioğlu D, Erdem G, Tülek N, Yurdakök M: Neonatal and maternal serum levels of soluble ICAM-1 in preeclamptic and normal pregnancies. Am J Perinatol 2002;19:333–339.
- Morken NH, Källen K, Hagberg H, Jacobsson B: Preterm birth in Sweden 1973–2001: rate, subgroups, and effect of changing patterns in multiple births, maternal age, and smoking. Acta Obstet Gynecol Scand 2005;84:558–565.
- Moutquin JM: Classification and heterogeneity of preterm birth. BJOG 2003;110:30–33.
- Patni S, Flynn P, Wynen LP, Seager AL, Morgan G, White JO, Thornton CA: An introduction to Toll-like receptors and their possible role in the initiation of labour. BJOG 2007;114:1326–1334.
- Adams Waldorf KM, Persing D, Novy MJ, Sadowsky DW, Gravett MG: Pretreatment with Toll-like receptor 4 antagonist inhibits lipopolysaccharide-induced preterm uterine contractility, cytokines, and prostaglandins in rhesus monkeys. Reprod Sci 2008;15:121–127.
- Engel SA, Erichsen HC, Savitz DA, Thorp J, Chanock SJ, Olshan AF: Risk of spontaneous preterm birth is associated with common proinflammatory cytokine polymorphisms. Epidemiology 2005;16:469–477.
Article / Publication Details
Received: August 05, 2008
Accepted: October 10, 2008
Published online: March 31, 2009
Issue release date: September 2009
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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