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Original Research Article

Effect of Some Alkaloids, Flavonoids and Triterpenoids, Contents of Japanese-Chinese Traditional Herbal Medicines, on the Lipogenesis of Sebaceous Glands

Seki T. · Morohashi M.

Author affiliations

Department of Dermatology, Toyama Medical and Pharmaceutical University, Toyama, Japan

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Skin Pharmacol 1993;6:56–60

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: April 17, 1992
Accepted: April 27, 1992
Published online: March 31, 2009
Issue release date: 1993

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

Abstract

The effects of some alkaloids and flavonoids, which are major ingredients in some of the Japanese Kampoh drugs (Japanese-Chinese traditional herbal medicines) experientially known to be efficacious for the treatment of acne vulgaris, on the lipogenesis in the sebaceous glands of the hamster ear, an excellent animal model for the human sebaceous gland, were studied. Lipogenesis was assayed by determining 14C incorporation into sebaceous lipids extracted from the sebaceous glands which were preincubated with 14C-acetate. We found that the lipogenesis in the hamster sebaceous glands was suppressed 63 and 54% by 10-4M berberine (an alkaloid) and wogonin (a flavonoid), respectively. We suggest that the therapeutic effects of some Japanese Kampoh drugs experientially used for acne vulgaris could be due to inhibition of lipogenesis by their active ingredients such as berberine and wogonin.

© 1993 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: April 17, 1992
Accepted: April 27, 1992
Published online: March 31, 2009
Issue release date: 1993

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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