Gerontology
Experimental Section
Bromocriptine, Dihydroergotoxine and Sleep in Rats: Effects of Repeated AdministrationRadulovacki M. · Brodie M. · Walovitch R. · Yanik G.Department of Pharmacology, University of Illinois Medical Center, Chicago, Ill., USA
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Article / Publication Details
Received: June 02, 1980
Accepted: June 24, 1980
Published online: April 06, 2009
Issue release date: 1981
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)
For additional information: https://www.karger.com/GER
Abstract
Bromocriptine mesylate (7.5 mg/kg, i.p.) and dihydroergotoxine mesylate (DHET; 3 mg/kg, i.p.) were administered 4 times at 9-hour intervals within a 27-hour period to rats poly-graphically recorded for 84 h. Administration of bromocriptine resulted in increased wakefulness and reduced slow-wave sleep (SWS) and rapid eye movement sleep (REM) during the 0- to 36-hour period. Reduction of SWS or REM during this time period was not followed by a rebound of SWS or REM during the next 36- to 84-hour period. In addition, there was a significant reduction of SWS during the entire 0- to 84-hour period. Administration of DHET to rats did not significantly affect sleep although there was a tendency for wakefulness to increase and for SWS and REM to decrease. It appears that the effects of repeated administration of the two ergot compounds on the sleep-wakefulness cycle in rats may be indicative of the drugs’ role in fulfillment of sleep ‘need’.
© 1981 S. Karger AG, Basel
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Article / Publication Details
Received: June 02, 1980
Accepted: June 24, 1980
Published online: April 06, 2009
Issue release date: 1981
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)
For additional information: https://www.karger.com/GER
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