Gerontology
Experimental Section
Aging-Associated Pancreatic Exocrine Insufficiency in the Unanesthetized RatHollander D. · Dadufalza V.D.Division of Gastroenterology and the Departments of Medicine, Physiology and Biophysics, University of California, Irvine, and the Long Beach Veterans Administration Medical Center, Long Beach, Calif, USA
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Received: November 03, 1983
Accepted: January 12, 1984
Published online: April 06, 2009
Issue release date: 1984
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)
For additional information: https://www.karger.com/GER
Abstract
Observations in individuals have suggested that pancreatic functions may be diminished with aging. In order to explore this possibility, we measured pancreatic fluid, protein and amylase output as a function of aging in the rat. Surgical preparations of the rats included external drainage of pancreatic secretions without obstructing normal bile flow and complete diversion of gastric acid out of the duodenum to prevent endogenous secretin release. Pancreatic secretions were collected in the basal state in unanesthetized animals 24 h after surgery. Protein and amylase output were highest at 3 months of age and decreased to less than 20% of maximal values by 27 months of age. For example, amylase output decreased from 4,354 to 105 U/h/kg and protein output fell from 33.5 to 1.7 mg/h/kg between 3 and 27 months of age. Our findings indicate that aging in the rat is associated with diminished pancreatic exocrine functions. Further careful assessment of pancreatic functions in aging individuals is advisable.
© 1984 S. Karger AG, Basel
Related Articles:
Article / Publication Details
Received: November 03, 1983
Accepted: January 12, 1984
Published online: April 06, 2009
Issue release date: 1984
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)
For additional information: https://www.karger.com/GER
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Get Permission