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Original Paper

Echinacea purpurea Polysaccharide Reduces the Latency Rate in Herpes Simplex Virus Type-1 Infections

Ghaemi A.a, b · Soleimanjahi H.d · Gill P.c · Arefian E.d · Soudi S.e · Hassan Z.e

Author affiliations

aFaculty of Medicine, Golestan University of Medical Sciences and Health Care, Gorgan, bYoung Researchers’ Club, Tehran Science and Research Campus, IAU, cDepartment of Nanobiotechnology, Faculty of Basic Sciences, and Departments of dVirology and eImmunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Corresponding Author

Amir Ghaemi, Hoorieh Soleimanjahi

Department of Virology, School of Medical Sciences, Tarbiat Modares University

P.O. Box 14115-111, Tehran (Iran)

Tel. +98 21 8801 3561, Fax +98 21 8801 3030

E-Mail ghaem_amir@yahoo.com or soleim_h@modares.ac.ir

Related Articles for ""

Intervirology 2009;52:29–34

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Abstract

Objective: During the latency period of herpes simplex virus type-1 (HSV-1), the virus can occasionally reactivate, travel back to the eye and cause recurrent ocular disease. As this condition arises from the ability of HSV-1 to produce a dormant infection, effective medication to prevent the virus enter a latent state should prevent it. In this study, we applied Echinacea polysaccharide (EP) fraction as prophylactic mediator for latency prevention. Methods: In order to investigate the protective properties of EP, we evaluated its immunostimulatory functions on different immune aspects that play important roles in latency prevention (particularly IFN-γ as one of the main indicators of cellular immunity and latency). Finally, we assessed establishment of latency by detection of thymidine kinase gene in trigeminal ganglia of BALB/c mice. Results: We demonstrated that EP promotes immune response, leading to a reduced latency rate, and it has a promising effect on latency prevention. Conclusion: EP was able to exert an antiviral action on the development of recurrent HSV-1 disease when supplied prior to infection.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 12, 2008
Accepted: February 22, 2009
Published online: April 17, 2009
Issue release date: May 2009

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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