Gerontology
Experimental Section
(Na+-K+)-ATPase Activity and Ouabain-Binding Sites in the Cerebral Cortex of Young and Aged Fischer-344 RatsLaManna J.C. · Doull G. · McCracken K. · Harik S.I.Case Western Reserve University School of Medicine, Department of Neurology, Cleveland, Ohio, USA
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Published online: April 08, 2009
Issue release date: 1983
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)
For additional information: https://www.karger.com/GER
Abstract
(Na+-K+)-ATPase is an enzyme responsible for ionic homeostasis in excitable tissues. Thus, the activity of this enzyme is essential for the maintenance of optimal function of the cerebral cortex. Although abnormalities of cerebral oxidative metabolism have been described in aging, these abnormalities do not appear to be associated with changes in the in vitro enzyme characteristics of (Na+-K+)-ATPase. Specifically, there were no significant differences between preparations from the cerebral cortex of 3- and 28-month-old Fischer-344 rats in their: (i) high-affinity binding to [3H]-ouabain, (ii) number of ouabain-binding sites, or (iii) K+p-nitrophenylphosphatase activity.
© 1983 S. Karger AG, Basel
Related Articles:
Article / Publication Details
Published online: April 08, 2009
Issue release date: 1983
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)
For additional information: https://www.karger.com/GER
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Get Permission