Pathophysiology of Haemostasis and Thrombosis

 

Pre- and Post-Operative Studies of Fibrinolysis and Prothrombin in Cyanotic Congenital Heart Disease

Ekert H. · Sheers M.

Author affiliations

Royal Children’s Hospital Research Foundation, Melbourne, Victoria

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Haemostasis 1974;3:158–166

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: June 05, 1974
Accepted: August 05, 1974
Published online: April 15, 2009
Issue release date: 1974

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT

Abstract

Multiple components of the fibrinolytic mechanism (plasminogen, plasmin, antiplasmin, fibrinogen, fibrin degradation products) and factor II (prothrombin) levels were studied in 40 children with cyanotic congenital heart disease (CCHD) prior to corrective surgery. Seven of these were also studied post-operatívely. A further 17 children were studied after corrective surgery only. Pre-operatively, increased fibrinolysis could be demonstrated in only 7.5–12% of patients, and there was no correlation between the levels of fibrinolytic components and the severity of polycythemia or post-operative blood loss. There was no evidence of fibrinolysis post-operatively. Pre-operatively, low prothrombin levels were common (25 %), were correlated with the amount of post-operative blood loss and were restored to normal by corrective surgery. Hypoprothrombinaemia is one of the most significant haematological abnormalities in CCHD.

© 1974 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: June 05, 1974
Accepted: August 05, 1974
Published online: April 15, 2009
Issue release date: 1974

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT


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