Pathophysiology of Haemostasis and Thrombosis

 

Ditazole and Platelets

I. Effect of Ditazole on Human Platelet Function in vitro

de Gaetano G. · Tonolli M.C. · Bertoni M.P. · Roncaglioni M.C.

Author affiliations

Laboratory for Haemostasis and Thrombosis Research, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan

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Haemostasis 1977;6:127–136

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: August 06, 1976
Accepted: November 25, 1976
Published online: April 16, 2009
Issue release date: 1977

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT

Abstract

Ditazole (4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) has been shown to be a strong in vitro inhibitor of human platelet aggregation brought about by release reaction inducers; in contrast, it did not significantly affect primary ADP-induced aggregation. Ditazole strongly inhibited the release of platelet-bound 14C-serotonin under the influence of Thrombofax, whereas it did not interfere with the transport and storage of serotonin in nonstimulated platelets. The effect of ditazole was not potentiated by acetyl-salicylic acid. Ditazole also inhibited ADP-reptilase clot retraction and modified thrombin-induced clot formation. The inhibition of platelet aggregation exerted by ditazole in plasma could be removed following gel filtration of platelets on Sepharose 2-B gel. This would indicate that ditazole does not act on platelets by a ‘hit and run’ mechanism.

© 1977 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: August 06, 1976
Accepted: November 25, 1976
Published online: April 16, 2009
Issue release date: 1977

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT


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