Pathophysiology of Haemostasis and Thrombosis
Original Paper
Plasmin Inhibitors in Different Fibrinolytic Treatment PatternsLasierra J. · Díez M. · Perera C. · Viladés E.Hematological Service (Chief: J. Lasierra), Residencia Sanitaria de la Seguridad Social, Logroño
Keywords: StreptokinaseUrokinaseAntiplasmin |
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Article / Publication Details
Received: April 15, 1979
Accepted: January 15, 1980
Published online: April 17, 2009
Issue release date: 1981
Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0
ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)
For additional information: https://www.karger.com/PHT
Abstract
The variations of different antiplasmins were studied in a group of patients suffering from thromboembolic conditions and receiving three different regimens of throm-bolytic treatment with streptokinase and urokinase. The evaluation of the antiproteases was carried out by chromogenic substrate and radial immunodiffusion. The different administration patterns of the fibrinolytic agents were followed by a clear drop in fast antiplasmin and α2-macroglobulin, while α1-antitrypsin was increased. Antifhrombin-III activity was reduced while its protein rose in the intermittent treatment with streptokinase. In the conventional treatment with streptokinase, both the activity and the protein of antithrobin-III increased. With urokinase both the protein and the activity of antithrombin-III were slightly reduced. Plasminogen and fibrinogen decreased in the different regimens of thrombolytic treatment, being more evident in continuous administration of streptokinase.
© 1981 S. Karger AG, Basel
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Article / Publication Details
Received: April 15, 1979
Accepted: January 15, 1980
Published online: April 17, 2009
Issue release date: 1981
Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0
ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)
For additional information: https://www.karger.com/PHT
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