Pathophysiology of Haemostasis and Thrombosis
Original Paper
Factor XI Kinetics after Plasma Exchange in Severe Factor XI DeficiencyNováková I.R.O.a · van Ginneken C.A.M.b · Verbruggen H.W.a · Haanen C.aaDivision of Hematology, Department of Internal Medicine, and bDepartment of Pharmacology, University of Nijmegen, The Netherlands
I.R.O Nováková, Division of Hematology, Department of Internal Medicine, University Hospital St. Radboud, 8 Geert Grooteplein Zuid, NL-6525 GA Nijmegen (The Netherlands) |
|
Abstract
Plasma exchange in a patient with factor XI deficiency allowed the determination of the factor XI disappearance time. The decay curve showed a biphasic pattern with a t½ of 12.3 h during the first 3 days, followed by a slower decay with a t½ of 121 h. After a loading dose by means of plasma exchange with fresh frozen plasma (FFP) up to a factor XI level of 65%, administration of 0.5 liter FFP every 12 h was necessary to maintain the factor XI concentration between 40 and 60%. The clearances of factor XI, calculated from the results of plasma exchange and from the maintenance dose, correlated very well and showed that the t½ of factor XI did not change after surgery. The patient underwent major surgery uneventfully but ultimately died 3½ weeks after operation from cerebral damage due to cardiac arrest, which occurred on the 2nd postoperative day.
© 1986 S. Karger AG, Basel
Related Articles:
Article / Publication Details
Received: June 10, 1985
Accepted: November 15, 1985
Published online: April 21, 2009
Issue release date: 1986
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)
For additional information: https://www.karger.com/PHT
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
