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Editor's Choice - Free Access

Prefrontal Plasticity and Stress Inoculation-Induced Resilience

Katz M.a · Liu C.b · Schaer M.c, d · Parker K.J.a · Ottet M.-C.c · Epps A.a · Buckmaster C.L.a · Bammer R.b · Moseley M.E.b · Schatzberg A.F.a · Eliez S.c · Lyons D.M.a

Author affiliations

Departments of aPsychiatry and bRadiology, Stanford University, Stanford, Calif., USA; cDivision of Child and Adolescent Psychiatry, Geneva University, Geneva, and dSignal Processing Institute, Swiss Federal Institute of Technology, Lausanne, Switzerland

Corresponding Author

David M. Lyons

1201 Welch Rd


Stanford, CA 94305-5485 (USA)

Tel. +1 650 725 5931, Fax +1 650 498 7761, E-Mail dmlyons@stanford.edu

Related Articles for ""

Dev Neurosci 2009;31:293–299

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Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Stress

Received: January 09, 2009
Accepted: January 09, 2009
Published online: June 17, 2009
Issue release date: June 2009

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

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