Pathophysiology of Haemostasis and Thrombosis

Original Paper

Differences in Plasminogen Activator Inhibitor 1 Activity between Blacks and Whites May Be Diet Related

Jerling J.C. · Vorster H.H. · Oosthuizen W. · Silvis N. · Venter C.S.

Author affiliations

Nutrition Research Group, Department of Nutrition, Potchefstroom University for Christian Higher Education, Potchefstroom, South Africa

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Haemostasis 1994;24:364–368

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 13, 1993
Accepted: May 30, 1994
Published online: April 28, 2009
Issue release date: 1994

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT

Abstract

Two matched groups of healthy non-smoking male volunteers between 18 and 23 years old and with a body mass index of 19-24 kg/m2 were selected from urban whites (n = 15) and from rural Vendas (blacks; n = 17). Fasting venous blood samples were collected between 07.00 and 10.00 h, and a validated food frequency questionnaire was administered. The results showed highly significant differences in dietary patterns. Significant differences were observed with regard to serum cholesterol (p < 0.02), percentage high-density lipoprotein cholesterol (p < 0.02), calculated insulin sensitivity index (p < 0.04), and plasma fibrinogen levels (p < 0.03). Tissue plasminogen activator antigen did not differ significantly. The plasminogen activator inhibitor 1 activity was significantly lower (p < 0.0001) in the Vendas than in the whites. It is concluded that diet may be an important determinant of plasminogen activator inhibitor 1 activity.

© 1994 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 13, 1993
Accepted: May 30, 1994
Published online: April 28, 2009
Issue release date: 1994

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT


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