Annals of Nutrition and Metabolism
Original Paper
Familial Aggregation of the Metabolic Syndrome: Tehran Lipid and Glucose StudyAzizi F. · Farahani Z.K. · Ghanbarian A. · Sheikholeslami F. · Mirmiran P. · Momenan A.A. · Asl S.Z. · Hadaegh F. · Eskandari F.Endocrine Research Center, Shahid Beheshti University (M.C.), Tehran, I.R. Iran
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Received: January 14, 2008
Accepted: March 06, 2009
Published online: May 06, 2009
Issue release date: August 2009
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 7
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
Abstract
Aims: Familial aggregation of the metabolic syndrome has been reported in some nations. The aim of this study was to evaluate familial aggregation of the metabolic syndrome in Tehranian families. Methods: In a cross-sectional study, anthropometry, blood pressure and biochemical data were collected for 4,558 individuals in the Tehran Lipid and Glucose Study. Variables of the metabolic syndrome in offspring were correlated with those of their parents. Results: There were 1,274 fathers, 1,576 mothers, 802 sons and 906 daughters. Prevalence of metabolic syndrome was 24.4% for fathers, 39.7% for mothers, 9.0% for sons and 7.6% for daughters. Triglycerides and HDL-C of children whose fathers had metabolic syndrome, and BMI, triglycerides and HDL-C of those whose mothers had it were significantly different from those adolescents whose parents were free of metabolic syndrome. Compared with children whose parents did not have metabolic syndrome, the odds ratio (confidence interval) for children with both parents having metabolic syndrome was 4.53 (2.42–8.8) for metabolic syndrome, 2.22 (1.17–4.19) for abdominal obesity, 1.90 (1.15–3.13) for high blood pressure, 2.66 (1.77–4.00) for low HDL-C and 3.16 (2.10–4.75) for high triglyceride levels. Conclusion: This survey provides evidence suggesting that there is a familial aggregation of the metabolic syndrome among Iranian families.
© 2009 S. Karger AG, Basel
Related Articles:
References
- Reaven GM: Banting lecture 1988: role of insulin resistance in human disease. Diabetes 1988;37:1595–1607.
-
Schmidt MI, Watson RL, Duncan BB, Metcalf P, Brancati FL, Sharret AR, Davis CE, Heiss G: Clustering of dyslipidemia, hyperuricemia, diabetes, and hypertension and its association with fasting insulin and central and overall obesity in a general population. Atherosclerosis Risk in Communities Study Investigators. Metabolism 1996;45:699–706.
External Resources
- Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III): final report. Circulation 2002;106:3143–3421.
- Carmelli D, Cardon LR, Fabsitz R: Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environment? Am J Hum Genet 1994;55:566–573.
- Mirmiran P, Mirbolooki M, Azizi F: Familial clustering of obesity and the role of nutrition: Tehran Lipid and Glucose Study. Int J Obes Relat Metab Disord 2002;26:1617–1622.
- Perusse L, Rice T, Despres JP, Bergeron J, Province MA, Gagnon J, Leon SA, Rao DC, Skinner JS, Wilmore JH, Bouchard C: Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the Heritage family study. Arterioscler Thromb Vasc Biol 1997;17:3263–3269.
- Poulsen P, Vaag A: Glucose and insulin metabolism in twins: influence of zygosity and birth weight. Twin Res 2001;4:350–355.
- Jee SH, Suh II, Won SY, Kim M: Familial correlation and heritability for cardiovascular risk factors. Yonsei Med J 2002;43:160–164.
- Flodmark CE, Ohlsson T, Ryden O, Sveger T: Prevention of progression to severe obesity in a group of obese school children treated with family therapy. Pediatrics 1993;91:880–884.
- Wadden TA, Stunkard AJ, Rich L, et al: Obesity in black adolescent girls: a controlled clinical trial of treatment by diet, behaviour modification, and parental support. Pediatrics 1990;85:345–352.
- Azizi F, Salehi P, Etemadi A, Zahedi-Asl S: Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study. Diabetes Res Clin Pract 2003;61:29–37.
-
Esmaillzadeh A, Mirmiran P, Azadbakht L, Etemadi A, Azizi F: High prevalence of the metabolic syndrome in Iranian adolescents. Obesity 2006;14:377–382.
External Resources
- Lee KE, Klein BE, Klein R: Familial aggregation of components of the multiple metabolic syndrome in the Framingham heart and offspring cohorts: genetic analysis workshop problem 1. BMC Genet 2003;4:S94.
- Park HS, Park JY, Cho S: Familial aggregation of the metabolic syndrome in Korean families with adolescents. Atherosclerosis 2005;186:215–221.
-
Tang W, Hong Y, Province MA, Rich SS, Hopkins PN, Arnett DK, Pankow JS, Miller MB, Eckfeldt JH: Familial clustering for features of the metabolic syndrome: the National Heart, Lung and Blood Institute (NHLBI) Family Heart Study. Diabetes Care 2006;29:631–636.
-
Azizi F, Rahmani M, Emami H, Madjid M: Tehran Lipid and Glucose Study: rational and design. CVD Prev 2000;3:242–247.
- Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499–502.
-
World Health Organization: Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation on Obesity. Geneva 3–5 June, 1997.
- Duncan GE, Li SM, Zhou XH: Prevalence and trends of a metabolic syndrome phenotype among US adolescents. Diabetes Care 2004;27:2438–2443.
-
Mirmiran P, Mirbolooki M, Mohammadi nasrabadi F, Azizi F: Prevalence of thinness, overweight and obesity in Tehran adolescents: Tehran Lipid and Glucose Study (in Persian). IJEM 2004;5:371–378.
-
Azadbakht L, Mirmiran P, Azizi F: Prevalence and associates of obesity in Tehran adults: Tehran Lipid and Glucose Study (in Persian). IJEM 2004;5:379–388.
- Azadbakht L, Mirmiran P, Shiva N, Azizi F: General obesity and central adiposity in a representative sample of Tehranian adults: prevalence and determinants. Int J Vitam Nutr Res 2005;75:347–356.
- Ferrannini E, Haffner SM, Mitchel BD, Stern MP: Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome. Dibetologia 1991;34:416–422.
- Schmidt MI, Watson RL, Duncan BB, et al: Clustering of dislipidemia, hyperuricemia, diabetes, and hypertension and its association with fasting insulin and central and overall obesity in a general population. Atherosclerosis Risk in Communities Study investigators. Metabolism 1996;45:699–706.
-
Schmidt MI, Duncan BB, Watson RL, Sharrett AR, Brancati FL, Heiss G: A metabolic syndrome in whites and African-Americans. The Atherosclerosis Risk in Communities Baseline Study. Diabetes Care 1996;19:414–418.
External Resources
- Poulsen P, Vaag A, Kyvik K, Beck-Nielsen H: Genetic versus environmental aetiology of the metabolic syndrome among male and female twins. Diabetologia 2001;44:537–543.
- Freeman MS, Mansfield MW, Barrett JH, Grant PJ: Heritability of features of the insulin resistance syndrome in a community-based study of healthy families. Diabet Med 2002;19:994–999.
- Mills GW, Avery PJ, McCarthy MI, et al: Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes. Diabetologia 2004;47:732–738.
- Beck-Nielsen H: General characteristics of the insulin resistance syndrome: prevalence and heritability. European Group for the Study of Insulin Resistance (EGIR). Drugs 1999;58(suppl 1):7–10; discussion 75–82.
- Mitchell BD, Kammere CM, Mahaney MC, et al: Genetic analysis of the IRS: pleitropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscler Thromb Vasc Biol 1996;16:281–288.
Article / Publication Details
Received: January 14, 2008
Accepted: March 06, 2009
Published online: May 06, 2009
Issue release date: August 2009
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 7
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
