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Original Paper

Free Access

Proviral Loads and Clonal Expansion of HTLV-1-Infected Cells following Vertical Transmission: A 10-Year Follow-Up of Children in Jamaica

Umeki K.a · Hisada M.b · Maloney E.M.c · Hanchard B.d · Okayama A.a

Author affiliations

aDepartment of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan; bDivision of Cancer Epidemiology and Genetics, NCI, Rockville, Ind., and cCenters for Disease Control and Prevention, Atlanta, Ga., USA; dDepartment of Pathology, University of the West Indies, Mona, Jamaica

Corresponding Author

Akihiko Okayama, MD, PhD

Department of Rheumatology, Infectious Diseases and Laboratory Medicine

Faculty of Medicine, University of Miyazaki

5200 Kihara, Kiyotake, Miyazaki 889-1692 (Japan)

Tel. +81 985 7284, Fax +81 985 85 4709, E-Mail okayama@med.miyazaki-u.ac.jp

Related Articles for ""

Intervirology 2009;52:115–122

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Objective: Few studies have specifically examined proviral load (PVL) and clonal evolution of human T-lymphotropic virus type 1 (HTLV-1)-infected cells in vertically infected children. Methods: Sequential samples (from ages 1 to 16 years) from 3 HTLV-1-infected children (cases A, B and C) in the Jamaica Mother Infant Cohort Study were analyzed for their PVL and clonal expansion of HTLV-1-infected cells in peripheral blood mononuclear cells (PBMCs) by inverse-long PCR. Results: The baseline PVL (per 100,000 PBMCs) of case A was 260 (at 1 year of age) and of case B it was 1,867 (at 3 years of age), and they remained constant for more than 10 years. Stochastic patterns of clonal expansion of HTLV-1-infected cells were predominately detected. In contrast, case C, who had lymphadenopathy, seborrheic dermatitis and hyperreflexia, showed an increase in PVL from 2,819 at 1.9 years to 13,358 at 13 years of age, and expansion of 2 dominant clones. Conclusion: The clonal expansion of HTLV-1-infected cells is induced in early childhood after infection acquired from their mothers. Youths with high PVL and any signs and symptoms associated with HTLV-1 infection should be closely monitored.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 20, 2008
Accepted: March 25, 2009
Published online: May 20, 2009
Issue release date: June 2009

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

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