Chemotherapy
Interaction Aspects of Antimycobacterial Drugs in the Chemotherapy of TuberculosisII. The Role of Rifampicin and Other Drugs in the Dependent or Independent Action of Drug Associations in vitro Research Institute for Tuberculosis and Respiratory Diseases, Prague
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Article / Publication Details
Published online: May 25, 2009
Issue release date: 1974
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
Abstract
The concentration related interaction of rifampicin, in associations with isoniazid, ethambutol, streptomycin and p-aminosalicylic acid on M. tuberculosis (H37Rv) in vitro has been statistically evaluated. The independency or dependency of drugs has been assessed either on the basis of their concentrations or their proportions in associations studied. The effect of drug-resistant mutants has been excluded. The data indicate that rifampicin and ethambutol act dependently in a wide range of concentrations and proportions, both drugs participate equally on the increased effectivity of a given association. In associations of rifampicin with other drugs the dependent (increased) interaction is limited to some concentrations, particularly of rifampicin.
© 1974 S. Karger AG, Basel
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Article / Publication Details
Published online: May 25, 2009
Issue release date: 1974
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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