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Main Paper

Mechanisms of Hypercoagulation in Malignancy and during Chemotherapy

Falanga A.

Author affiliations

Haematology Division, Ospedali Riuniti, Bergamo, Italy

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Haemostasis 1998;28(suppl 3):50–60

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Article / Publication Details

First-Page Preview
Abstract of Main Paper

Published online: November 17, 2004
Issue release date: November 1998

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 4

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT

Abstract

Patients with cancer are at increased risk for thromboembolic disease. Commonly they present with abnormalities of one or more circulating markers of haemostatic system activation, underlying a ‘hypercoagulable state’. Despite numerous investigations which have identified alterations in all of the haemostatic components (i.e. coagulation, fibrinolysis, endothelium, platelets and monocytes), no firm conclusions have been reached regarding the clinical utility of any of these coagulation markers for predicting thrombosis in cancer patients. The predictive value of one or more of these tests could help to identify safe and effective methods for prophylaxis against thrombotic complications in these patients. Plasma clotting abnormalities are usually exacerbated by chemotherapy. The mechanisms by which the haemostatic system is activated in malignancy (and chemotherapy) are reviewed.


References

  1. Rickles FR, Edwards RL: Activation of blood coagulation in cancer Trousseau’s syndrome revisited. Blood 1983;62:14–31.
  2. Donati MB: Cancer and thrombosis from phlegmasia alba dolens to transgenic mice. Thromb Haemost 1995;74:278–281.
    External Resources
  3. Barbui T, Finazzi G, Falanga A: The impact of all-trans-retinoic acid on the coagulopathy of acute promyelocytic leukemia. Blood 1998;91:3093–3102.
  4. Salzman EW, Hirsh J: Prevention of venous thromboembolism: in Colman RW, Hirsh J, Marder VJ, Salzman EW (eds): Haemostasis and Thrombosis. Basic principles and clinical practice. Philadelphia, Lippincott, 1987, pp 1252–1265.
  5. Falanga A, Ofosu FA, Cortelazzo S, Delaini F, Consonni R, Caccia R, Longatti S, Maran D, Rodeghiero F, Pogliani E, Marassi A, D’Angelo A, Barbui T: Preliminary study to identify cancer patients at high risk of venous thrombosis following major surgery. Br J Haematol 1993;85:745–750.
  6. Barbui T, Finazzi G, Donati MB, Falanga A: Antiblastic therapy and thrombosis; in GG Neri Serneri, R Abbate, G Gensini, D Prisco (eds): Thrombosis an update. Florence, Scientific Press, 1992, pp 305–314.
  7. Levine MN, Gent M, Hirsh J, Arnold A, Goodyear MB, Hryniuk W, DePauw S: The thrombogenic effect of anticancer drug therapy in women with Stage II Breast Cancer. New Engl J Med 1998;318:404–407.
  8. Levine MN, Hirsh J, Gent M, Arnold A, Falanga A, Samosh M, Bramwell V, Pritchard KI, Stewart D, Goodwin P: Double-blind randomized trial of very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer. Lancet 1994;343:886–889.
  9. Rickles FR, Levine MN, Edwards RL: Hemostatic alterations in cancer patients. Cancer Met Rev 1992;11:237–248.
    External Resources
  10. Falanga A, Barbui T, Rickles FR, Levine MN: Guidelines for clotting studies in cancer patients. Thromb Haemost 1993;70:343–50.
  11. Falanga A, Ofosu FA, Delaini F, Oldani E, Dewar L, Lui L, Barbui T: The hypercoagulable state in cancer evidence for impaired thrombin inhibition. Blood Coag Fibrin 1994;5(suppl):19–223.
  12. Poggi A, Donati MB and Garattini S: Fibrin and cancer cell growth: Problems in the evaluation of experimental models: in Donati MB, Davison JF and Garattini S (eds): Malignancy and the Hemostatic System. Raven Press, 1981, pp 89–101.
  13. Bani MR, Falanga A, Alessio MG, Radice E, Consonni R, Giavazzi R, Donati MB: Blood coagulation changes in nude mice bearing human colon carcinomas. Int J Cancer 1992;50:75–79.
  14. Donati MB, Poggi A, Semeraro N: Coagulation and malignancy; in Poller L (ed): Recent Advances in Blood Coagulation. Churchill Livingstone, 1981, p.227–259.
  15. Falanga A, Iacoviello L, Evangelista V, Consonni R, Belotti D, D’Orazio A, Donati MB, Barbui T: Loss of blast cell procoagulant activity and improvement of hemostatic variables in patients with acute promyelocytic leukemia administered all-trans-retinoic acid. Blood 1995;86:1072–1081.
  16. Lindhal AK, Sandset PM, Abilgaard U: Indices of hypercoagulation in cancer as compared with those with acute inflammation and acute infarction. Haemostasis 1990;20:253–262.
  17. Seitz R, Rappe N, Kraus M, Immel A, Wolf M, Maasberg M, Edbring R, Pfab R, Havemann K: Activation of coagulation and fibrinolysis in patients with lung cancer relation to tumour stage and prognosis. Blood Coag Fibrin 1993;4:249–254.
  18. Kakkar AK, DeRuvo N, Chinswangwatanakul V, Tebbutt S, Williamson RCN: Extrinsic-pathway activation in cancer with high factor VIIa and tissue factor. Lancet 1995;346:1004–1005.
  19. Falanga A, Levine MN, Consonni R, Gritti G, Delaini F, Oldani E, Julian JA, Barbui T: The effect of very low dose warfarin on markers of hypercoagulation in metastatic breast cancer. Results from a randomized trial. Thromb Haemost 1998;79:23–27.
  20. Rocha E, Pàramo JA, Fernàndez FJ, Cuesta B, Hernandez M, Paloma MJ, Rifòn J: Clotting activation and impairment of fibrinolysis in malignancy. Thromb Res 189;54:699–707.
  21. Gadduci A, Baicchi U, Marrai R, Del Bravo B, Fosella PV, Facchini V: Pretreatment plasma levels of fibrinopeptide A (FPA), D-Dimer (DD), and von Willebrand factor (vWF) in patients with ovarian carcinoma. Gynec Oncol 1994;53:352–356.
  22. Licciarello JTW, Moake JL, Rudi CK, Karp DD, Hong WK: Elevated plasma von Willebrand Factor levels and arterial occlusive complications associated with cisplatin-based chemotherapy. Oncology 1985;42:296–300.
    External Resources
  23. Bazarbachi A, Scrobohachi ML, Gisselbracht C, Marolleau JP, Mansi A, Brice P, Gorra P, Drouet L: Changes in protein C, factor VII and endothelial markers after autologous bone marrow transplantation possible implications in the pathogenesis of veno-occlusive disease. Nouv Revue fr Hémat 1993;35:135–140.
  24. Catani L, Gugliotta L, Vianelli N, Nocentini F, Baravelli S, Bandini G, Cirio TM, Tura S: Endothelium and bone marrow transplantation. Bone Marrow Transpl 1996;17:277–280.
    External Resources
  25. Semeraro N, Montemurro P, Conese M, Giordano D, Stella M, Restaino A, Cagnazzo G, Colucci M: Procoagulant activity of mononuclear phagocytes from different anatomical sites in patients with gynaecological malignancies. Int J Cancer 1990;45:251–254.
  26. Wehmeier A, Tschope D, Esser J, Menzel C, Nieuwenhuis HK, Schneider W: Circulating activated platelets in myeloproliferate disorders. Thromb Res 1991;61:271–278.
  27. Andoh D, Kubota T, Takada M, Tanaka H, Kobayashi N, Maekawa T: Tissue factor activity in leukemia cells. Special reference to disseminated intravascular coagulation. Cancer 1987;59:748–754.
    External Resources
  28. Nemerson Y: The tissue factor pathway of blood coagulation. Sem Hematol 1992;29:170–176.
  29. Falanga A, Gordon SG: Isolation and characterization of cancer procoagulant; A Cysteine proteinase from malignant tissue. Biochemistry 1985;245:5558–5561.
  30. Donati MB, Gambacorti-Passerini C, Casali B, Falanga A, Vannotti P, Fossati G, Semeraro N, Gordon SG: Cancer procoagulant in human tumour cells: Evidence from melanoma patients. Cancer Res 1986;46:6471–6474.
    External Resources
  31. Gordon SG, Hashiba U, Poole MA, Cross BA, Falanga A: Cysteine proteinase procoagulant from amnion-chorion. Blood 1985;66:1261–1265.
    External Resources
  32. Van de Water L, Tracy PB, Aronson D, Mann KG, Dvorak HF: Tumour cell generation of thrombin via functional prothrombinase assembly. Cancer Res 1985;45:5521–5525.
    External Resources
  33. Edwards RL, Silver J, Rickles FR: Human tumour procoagulants: Registry of the Subcommittee on Haemostasis and Malignancy of the Scientific and Standardization Committee, International Society of Thrombosis and Haemostasis. Thromb Haemost 1993;63:205–213.
  34. Gordon SG: Tumour cell procoagulants and their role in malignant disease. Sem Thromb Haemost 1992;18:424–433.
  35. Falanga A, Consonni R, Marchetti M, Locatelli G, Garattini E, Gambacorti Passerini C, Gordon SG, Barbui T: Cancer procoagulant and tissue factor are differently modulated by all-trans-retinoic acid (ATRA) in acute promyelocytic leukemia cells. Blood 1998;92:143–151.
  36. Semeraro N, Colucci M: Tissue factor in health and disease. Thromb Haemost 1997;78:759–764.
  37. Donati MB, Falanga A, Consonni R, Alessio MG, Bassan R, Buelli M, Bolrin L, Catani L, Pogliani E, Gugliotta L, Masera G, Barbui T: Cancer procoagulant in acute non lymphoid leukemia relationship of enzyme detection to disease activity. Thromb Haemost 1990;64:11–16.
  38. Kwaan HC, Keet HN: Fibrinolysis and cancer. Semin Thromb Haemost 1990;16:230–235.
  39. Stephens R, Alitalo R, Tapiovaara H, Vaheri A: Production of an active urokinase by leukemia cells. A novel distinction from cell lines of solid tumours. Leuk Res 1988;12:419–422.
    External Resources
  40. Hajjar KA: Cellular receptors in the regulation of plasmin generation. Thromb Haemost 1995;74:294–301.
  41. Bevilacqua MP, Pober JS, Majeau GR, Fiers W, Cotran RS, Gimbrone MA Jr: Recombinant tumour necrosis factor induces procoagulant activity in cultured human vascular endothelium. Characterization and comparison with the actions of interleukin-1. Proc Natl Acad Sci USA 1986;83:4533–4537.
  42. Moore KL, Esmon NL: Tumour necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 1989;73:159–165.
  43. Falanga A, Marchetti M, Giovanelli S, Barbui T: All-trans-retinoic acid counteracts endothelial cell procoagulant activity induced by a human promyelocytic leukemia-derived cell line (NB4). Blood 1996;87:613–617.
  44. Van Hinsbergh VW, Bauer KA, Kooistra T, Kluft C, Dooijewaard G, Sherman ML, Nieuwenhuizen W: Progress of fibrinolysis during tumour necrosis factor infusion in humans. Concomitant increase of tissue-type plasminogen activator, plasminogen activator inhibitor type-1, and fibrin(ogen) degradation products. Blood 1990;76:2284–2289.
  45. Honn KV, Tang DG, Chen YQ: Adhesion molecules and site-specific metastases; in Neri Serneri GG, Abbate R, Gensini G, Prisco D (eds): Thrombosis an Update. Florence, Scientific Press, 1992, pp 269–303.
  46. Marchetti M, Falanga A, Giovanelli S, Oldani E, Barbui T: All-trans-retinoic acid increases adhesion to endothelium of the human promyelocytic leukemia cell line NB4. Br J Haematol 1996;93:360–366.
  47. Giavazzi R, Foppolo M, Dossi R, Remuzzi A: Rolling and adhesion of human tumour cells on vascular endothelium under physiological flow conditions. J Clin Invest 1993;92:3038–3044.
  48. Contrino J, Hair G, Kreutzer DL, Rickles FR: In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med 1996;2:209–215.
  49. Lorenzet R, Peri G, Locati D, Allavena P, Colucci M, Semeraro N, Mantovani A, Donati MB: Generation of procoagulant activity by mononuclear phagocytes A possible mechanism contributing to blood clotting activation within malignant tissue. Blood 1983;62:2721–2723.
  50. Poggi A, Rossi C, Beviglia L, Calabrese R, Donati MB: Platelets-tumour cell interactions; in Joseph M (ed): The handbook of immunopharmacology. London, Academic Press, 1995, pp 151–165.
  51. Al-Mondhiry H: Betathromboglobulin and platelet factor 4 in patients with cancer. Correlation with the stage of disease and the effect of chemotherapy. Am J Hematol 1983;14:105–111.
    External Resources
  52. Gasic GJ, Gasic TB: Plasma membrane vesicles as mediators of interactions between tumour cells and components of the haemostatic and immune system; in Jamieson GA (ed): Interactions of platelets and tumour cells. New York, Liss, 1982, pp 429.
  53. Grignani G, Jamieson GA: Platelets in tumour metastasis generation of ADP by tumour cells is specific but not unrelated to metastatic potential. Blood 1988;71:844–849.
    External Resources
  54. Bertomeu MC, Gallo S, Lauri D, Levine MN, Orr FW, Buchanan MR: Chemotherapy enhances endothelial cell reactivity to platelets. Clin Expl Metastasis 1990;8:511–518.
  55. Nicolson GL, Custead SE: Effects of chemotherapeutic drugs on platelet and metastatic tumour cell – endothelial cell interactions as a model for assessing vascular endothelial intergrity. Cancer Res 1985;45:331–336.
  56. Sporn LA, Rubin P, Marder VJ, Wagner DD: Irradiation induces release of von Willebrand protein from endothelial cells in culture. Blood 1984;64:567–570.
    External Resources
  57. Poggi A, Kornblitt L, Delaini F, Colombo T, Mussoni L, Reyers I, Donati MB: Delayed hypercoagulability after a single dose of adriamycin to normal rats. Thromb Res 1979;16:639–650.
    External Resources
  58. Walsh J, Wheeler HR, Geczy CL: Modulation of tissue factor on human monocytes by cisplatin and adriamycin. Br J Haematol 1992;81:480–488.
  59. Harper PL, Jarvis J, Jennings I, Luddington R, Marcus RE: Changes in the natural anticoagulants following bone marrow transplantation. Bone Marrow Transpl 1990;5:39–42.

Article / Publication Details

First-Page Preview
Abstract of Main Paper

Published online: November 17, 2004
Issue release date: November 1998

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 4

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT


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