Oncology

 

Hypothesis for the Mechanism of Elevated Serum Copper in Cancer Patients

Fisher G.L. · Shifrine M.

Author affiliations

Radiobiology Laboratory, School of Veterinary Medicine, University of California, Davis, California

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Oncology 1978;35:22–25

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 09, 2009
Issue release date: 1978

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL

Abstract

Neoplastic growths seem to interfere with normal processes regulating the serum level of ceruloplasmin, a copper-containing oxidase, which accounts for 96% of serum copper. Normal catabolism of ceruloplasmin in the liver follows desialylation. However, in patients with tumors, ceruloplasmin may be resialylated at the tumor cell surface or in peripheral blood. Decreased catabolism due to resialylation of asialo-ceruloplasmin could account for the increased concentration of serum copper noted in patients with neoplasia.

© 1978 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 09, 2009
Issue release date: 1978

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL


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