Oncology
Potentiating Role of Previously Administered Agents in the Combination Chemotherapy of Breast CancerRosner D. · Snyderman M. · Nemoto T.Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, N.Y.
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Article / Publication Details
Published online: June 10, 2009
Issue release date: 1979
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
Abstract
91 women with metastatic breast cancer, who received prior CTX-5FU or CTX-5FU-PRD, were treated in 3 consecutive clinical trials with either CTX-5FU-PRD-MTX-VCR, MTX-VCR, or MTX-VCR-PRD in order to elucidate whether the effectiveness of 5 drugs was due only to the newly added drugs (MTX-VCR ± PRD) or whether the previously used drugs (CTX-5FU) were necessary as potentiating agents. There were 17 of 39 responders (43%) in the 5-drug group, 3 of 25 (12%) in the MTX-VCR group and 3 of 27 (11%) in the MTX-VCR-PRD group. The survival in the group treated with 5 drugs was significantly longer. Our results show that CTX-5FU-PRD-MTX-VCR was significantly more effective than MTX-VCR or MTX-VCR-PRD used alone after the patient had already had CTX-5FU ± PRD. Thus, the previously used drugs (CTX-5FU) seemed to improve the response to the new agents (MTX-VCR ± PRD) by a potentiating action in the subsequent combination. It is concluded that the exploitation of this enhancing effect represents a significant improvement in the treatment options now available.
© 1979 S. Karger AG, Basel
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Article / Publication Details
Published online: June 10, 2009
Issue release date: 1979
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
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