Oncology

 

Intralesional Immune Therapy

Methanol Extraction Residue of BCG or Purified Protein Derivative

Lokich J.J. · Garnick M.B. · Legg M.

Author affiliations

Medical Oncology Division, Sidney Farber Cancer Institute; Harvard Medical School, and Division of Medical Oncology and Department of Pathology, New England Deaconess Hospital, Boston, Mass.

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Oncology 1979;36:236–241

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 10, 2009
Issue release date: 1979

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL

Abstract

6 patients with cutaneous malignant melanoma and multiple secondary cutaneous lesions were treated with intralesional methanol extraction residue of bacillus Calmette Guerin (MER-BCG). Separate lesions were injected with purified protein derivatives (PPD) in 5 of the study patients. 5 of the 6 MER-BCG injection lesions developed marked inflammation clinically. Excisional biopsy 7–14 days later demonstrated complete dissolution of tumor in 2 patients and was accompanied by infiltration with acute and chronic inflammatory cells; 3 lesions revealed necrosis with residual tumor, and in 1 patient there was no apparent host response. Clinical tumor regression was not observed with PPD applied intralesionally, although histopathologic analysis revealed a granulomatous inflammatory response in 3 of 5 patients. No patient demonstrated regression of uninjected cutaneous lesions (4 evaluable patients) or visceral lesions (2 patients). The critical determinants of tumor regression are the size, site and depth of the lesion in relationship to the cutaneous surface. The mechanism of tumor eradication may be related to ‘innocent bystander’ necrosis secondary to nonspecific inflammation rather than immunologically mediated via host sensitization.

© 1979 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 10, 2009
Issue release date: 1979

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL


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