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Risk Assessment of N-Nitroso Compounds for Human Health

A Model for Estimation of Human Exposure to Endogenous N-Nitrosodimethylamine

Tannenbaum S.R.

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Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Mass.

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Oncology 1980;37:232–235

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Article / Publication Details

First-Page Preview
Abstract of Risk Assessment of N-Nitroso Compounds for Human Health

Published online: June 10, 2009
Issue release date: 1980

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL

Abstract

A simple mathematical model is formulated to estimate the order of magnitude of the flux of N-nitrosodimethylamine, based upon blood concentrations and the assumption of a quasi steady state between formation and metabolism. The model predicts a total daily exposure which corresponds to an extrapolated risk well within the observed risk for liver cancer in the USA. The ramifications of this model are significant for cancer prevention and for the development of techniques of risk extrapolation.

© 1980 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Risk Assessment of N-Nitroso Compounds for Human Health

Published online: June 10, 2009
Issue release date: 1980

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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