Oncology
Original Paper
Antitumor Therapeutic Effect of Neurotropin on Transplanted Tumors in RatsMizushima Y.a,c · Wepsic H.T.a,b · Kobayashi H.caDepartment of Pathology, Loyola University Medical Center, Maywood, Ill.; bDepartment of Laboratory Services, Edward J. Hines, Jr. Veterans Administration Hospital, Hines, Ill.; USA; claboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
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Article / Publication Details
Published online: June 17, 2009
Issue release date: 1984
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
Abstract
The antitumor therapeutic effect of neurotropin (NSP) was examined using the moderately immunogenic KMT-17 tumor in WKA rats and the lower immunogenic 9098 tumor in ACI rats. Treatment with NSP was effective in causing tumor regression and of prolonging the mean survival time of animals which were inoculated with the KMT-17 tumor whereas it is ineffective with the 9098 tumor. Mitogen studies with 9098 tumor-bearing animals, which were treated with NSP, showed that the PHA-P mitogenic reactivity of spleen cells from NSP treated tumor bearing rats (TBR) was higher than that from NSP untreated TBR. When 9098 tumor bearing animals were given combination therapy with NSP and adriamycin (ADR), a beneficial therapeutic effect of NSP was observed. No adverse effect of NSP treatment was observed when it was given before, intermediate or after ADR treatment. These experiments demonstrate that immunomodulation by NSP may possibly have a beneficial therapeutic effect on tumor growth but the conditions to demonstrate this may be highly variable.
© 1984 S. Karger AG, Basel
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Article / Publication Details
Published online: June 17, 2009
Issue release date: 1984
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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