Oncology
Original Paper
Serial Determinations of Serum CEA in Monitoring Management of Patients with Colorectal CarcinomaBehbehani A.I.a · Al-Naqeeb N.a · Omar Y.T.b · El-Nas S.A.a · Al-Deen A.S.a · Awwad A.a · Al-Jazzaf H.a · Nasralla M.Y.c · Szymendera J.J.cDepartments of aSurgery and bRadiotherapy, and cTumor Biology Laboratory, Kuwait Cancer Control Center, Shuwaikh, Kuwait
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Article / Publication Details
Published online: June 26, 2009
Issue release date: 1990
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
Abstract
Serum concentrations were determined serially in two groups of patients with colorectal carcinoma: in 123 after curative resection and in 34 with residual cancer. Of the first group, in 98 serum CEA fluctuated within the normal range or with a 2-fold larger amplitude evidencing effective surgery because only 9 had recurrence; in 25 serum CEA rose persistently from a postoperative nadir indicating relapse, mostly liver metastases. Of the 34 patients with relapse, 3 had clinically and 7 CEA-directed second-look laparotomy; although 7 had operation with curative intent, only 3 remained disease-free. In the second group, there were 26 patients after palliative surgery and 8 during nonsurgical treatment. Serum CEA fluctuated within the normal range in 2 patients in remission and in 3 with progressive cancer, and rose in parallel to cancer progression in 29. Thus, serum CEA within or slightly above the normal range was 88% predictive that the patient might be free of disease or in remission; whereas elevated or rising level indicated disease progression. Accordance between serum CEA and clinical status occurred in 145 of 157 (92%) patients.
© 1990 S. Karger AG, Basel
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Article / Publication Details
Published online: June 26, 2009
Issue release date: 1990
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
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