Oncology

Platinum Etoposide Therapy in Non-Small Cell Lung Cancer

Carboplatin plus Oral Etoposide in the Management of Unresectable Non-Small Cell Lung Cancer

Preliminary Results of a Vanderbilt Trial

Johnson D.H. · Hainsworth J.D. · DeVore R. · Hande K.R. · Greco F.

Author affiliations

Division of Medical Oncology, Vanderbilt University School of Medicine, The Vanderbilt Clinic, Nashville. Tenn. USA

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Oncology 1992;49:57–62

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Article / Publication Details

First-Page Preview
Abstract of Platinum Etoposide Therapy in Non-Small Cell Lung Cancer

Published online: June 26, 2009
Issue release date: 1992

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL

Abstract

Forty-two patients with unresectable non-small cell lung cancer (NSCLC) were treated with carboplatin (300, 350 or 400 mg/nr) and 21 days of oral etoposide (50 mg/m2/day). Thirty-three patients were evaluable for response (too early to assess the remaining patients) and 9 patients (27%) achieved a partial remission. Median survival was 29 weeks (range, 4+ to 71 + weeks). The primary toxicity was myelosuppression. Leukocyte and platelet count nadirs occurred between days 22 and 29. In cycle 1, median leukocyte nadir was 2.8 x 109/1 and the platelet nadir was 142 x 109/1- Nonhematologic toxicities were modest and included alopecia in all patients, mild nausea, mild to moderate diarrhea, and an occasional increase in serum creatinine. Carboplatin plus oral etoposide is a tolerable outpatient regimen with modest activity against unresectable NSCLC.

© 1992 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Platinum Etoposide Therapy in Non-Small Cell Lung Cancer

Published online: June 26, 2009
Issue release date: 1992

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL


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