Photopic Negative Response Reflects Severity of Ocular Circulatory Damage after Central Retinal Artery OcclusionMatsumoto C.S. · Shinoda K. · Yamada K. · Nakatsuka K.
Department of Brain and Neuroscience, Ophthalmology, Oita University, Oita, Japan
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Purpose: To determine the relationship of the photopic negative response (PhNR) of the photopic electroretinogram (ERG) with the degree of circulatory disturbances in eyes following central retinal artery occlusion (CRAO). Methods: The circulatory disturbance was graded as mild (group 1) when the arm-to-retina transmission time was <30 s, moderate (group 2) when the time was >30 s and severe (group 3) when concurrent choroidal circulatory damage was found. For statistical analysis, groups 1, 2 and 3 were scored as 1, 2 and 3, respectively. Photopic ERGs were elicited by either short-flash (SF) or long-flash (LF) stimuli. Results: Both the SF and LF PhNR were significantly reduced in groups 2 and 3. The PhNR amplitude was negatively correlated with the severity of the ocular circulatory disturbances (p = 0.0498, ρ = –0.507 for SF PhNR; p = 0.0050, ρ = –0.750 for LF PhNR). Conclusion: The amplitude of the PhNR became more reduced as the severity of the circulatory disturbances increased in eyes with CRAO.
© 2009 S. Karger AG, Basel
- Yuzurihara D, Iijima H: Visual outcome in central retinal and branch retinal artery occlusion. Jpn J Ophthalmol 2004;48:490–492.
Sharma S, Brown GC: Retinal artery obstruction; in Ryan SJ (eds): Retina, ed 4. Philadelphia, Mosby, 2006, pp 1321–1338.
- Hayreh SS, Kolder HE, Weingeist TA: Central retinal artery occlusion and retinal tolerance time. Ophthalmology 1980;87:75–78.
- Hayreh SS, Zimmerman MB, Kimura A, Sanon A: Central retinal artery occlusion: retinal survival time. Exp Eye Res 2004;78:723–736.
- Carr R, Siegel I: Electrophysiologic aspects of several retinal diseases. Am J Ophthalmol 1964;58:95–107.
- Hamasaki DI, Kroll AJ: Experimental central retinal artery occlusion: an electrophysiological study. Arch Ophthalmol 1968;80:243–248.
Miyake Y: Central retinal artery occlusion; in Miyake Y (ed): Electrodiagnosis of Retinal Diseases. Tokyo, Springer, 2006, pp 181–182.
- Zhang Y, Cho CH, Atchaneeyasakul LO, McFarland T, Appukuttan B, Stout JT: Activation of the mitochondrial apoptotic pathway in a rat model of central retinal artery occlusion. Invest Ophthalmol Vis Sci 2005;46:2133–2139.
- Viswanathan S, Frishman LJ, Robson JG, Harwerth RS, Smith EL 3rd: The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma. Invest Ophthalmol Vis Sci 1999;40:1124–1136.
- Rangaswamy NV, Frishman LJ, Dorotheo EU, Schiffman JS, Bahrani HM, Tang RA: Photopic ERGs in patients with optic neuropathies: comparison with primate ERGs after pharmacologic blockade of inner retina. Invest Ophthalmol Vis Sci 2004;45:3827–3837.
- Machida S, Gotoh Y, Tanaka M, Tazawa Y: Predominant loss of the photopic negative response in central retinal artery occlusion. Am J Ophthalmol 2004;137:938–940.
- Chen H, Wu D, Huang S, Yan H: The photopic negative response of the flash electroretinogram in retinal vein occlusion. Doc Ophthalmol 2006;113:53–59.
- Viswanathan S, Frishman LJ, Robson JG, Walters JW: The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest Ophthalmol Vis Sci 2001;42:514–522.
- Miyata K, Nakamura M, Kondo M, Lin J, Ueno S, Miyake Y, Terasaki H: Reduction of oscillatory potentials and photopic negative response in patients with autosomal dominant optic atrophy with OPA1 mutations. Invest Ophthalmol Vis Sci 2007;48:820–824.
- Ueno S, Kondo M, Piao CH, Ikenoya K, Miyake Y, Terasaki H: Selective amplitude reduction of the PhNR after macular hole surgery: ganglion cell damage related to ICG-assisted ILM peeling and gas tamponade. Invest Ophthalmol Vis Sci 2006;47:3545–3549.
Nagata N: Studies on the photopic ERG of the human retina. Jpn J Ophthalmol 1963;7:96–124.
- Rufiange M, Rousseau S, Dembinska O, Lachapelle P: Cone-dominated ERG luminance-response function: the Photopic Hill revisited. Doc Ophthalmol 2002;104:231–248.
- Rosolen SG, Rigaudière F, LeGargasson JF, Chalier C, Rufiange M, Racine J, Joly S, Lachapelle P: Comparing the photopic ERG i-wave in different species. Vet Ophthalmol 2004;7:189–192.
- Sieving PA, Murayama K, Naarendorp F: Push-pull model of the primate photopic electroretinogram: a role for hyperpolarizing neurons in shaping the b-wave. Vis Neurosci 1994;11:519–532.
- Feghali J, Jin J, Odom JV: Effect of short-term intraocular pressure elevation on the rabbit electroretinogram. Invest Ophthalmol Vis Sci 1991;32:2184–2189.
- Johnson M, Drum B, Quigley HA: Pattern-evoked potential and optic nerve fiber loss in monocular laser-induced glaucoma. Invest Ophthalmol Vis Sci 1989;30:897–907.
Matsumoto H, Matsumoto CS, Nagata M, Nakatsuka K: Emergency treatment of simultaneous occlusion of central retinal artery and vein (in Japanese). Jpn J Clin Ophthalmol Rinsho Ganka 2005;59:923–927.
- Ueno S, Kondo M, Ueno M, Miyata K, Terasaki H, Miyake Y: Contribution of retinal neurons to d-wave of primate photopic electroretinograms. Vision Res 2006;46:658–664.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.