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Original Paper

Photopic Negative Response Reflects Severity of Ocular Circulatory Damage after Central Retinal Artery Occlusion

Matsumoto C.S. · Shinoda K. · Yamada K. · Nakatsuka K.

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Department of Brain and Neuroscience, Ophthalmology, Oita University, Oita, Japan

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Ophthalmologica 2009;223:362–369

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 20, 2007
Accepted: March 13, 2008
Published online: July 08, 2009
Issue release date: October 2009

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 1

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: https://www.karger.com/OPH

Abstract

Purpose: To determine the relationship of the photopic negative response (PhNR) of the photopic electroretinogram (ERG) with the degree of circulatory disturbances in eyes following central retinal artery occlusion (CRAO). Methods: The circulatory disturbance was graded as mild (group 1) when the arm-to-retina transmission time was <30 s, moderate (group 2) when the time was >30 s and severe (group 3) when concurrent choroidal circulatory damage was found. For statistical analysis, groups 1, 2 and 3 were scored as 1, 2 and 3, respectively. Photopic ERGs were elicited by either short-flash (SF) or long-flash (LF) stimuli. Results: Both the SF and LF PhNR were significantly reduced in groups 2 and 3. The PhNR amplitude was negatively correlated with the severity of the ocular circulatory disturbances (p = 0.0498, ρ = –0.507 for SF PhNR; p = 0.0050, ρ = –0.750 for LF PhNR). Conclusion: The amplitude of the PhNR became more reduced as the severity of the circulatory disturbances increased in eyes with CRAO.

© 2009 S. Karger AG, Basel


References

  1. Yuzurihara D, Iijima H: Visual outcome in central retinal and branch retinal artery occlusion. Jpn J Ophthalmol 2004;48:490–492.
  2. Sharma S, Brown GC: Retinal artery obstruction; in Ryan SJ (eds): Retina, ed 4. Philadelphia, Mosby, 2006, pp 1321–1338.
  3. Hayreh SS, Kolder HE, Weingeist TA: Central retinal artery occlusion and retinal tolerance time. Ophthalmology 1980;87:75–78.
  4. Hayreh SS, Zimmerman MB, Kimura A, Sanon A: Central retinal artery occlusion: retinal survival time. Exp Eye Res 2004;78:723–736.
  5. Carr R, Siegel I: Electrophysiologic aspects of several retinal diseases. Am J Ophthalmol 1964;58:95–107.
  6. Hamasaki DI, Kroll AJ: Experimental central retinal artery occlusion: an electrophysiological study. Arch Ophthalmol 1968;80:243–248.
  7. Miyake Y: Central retinal artery occlusion; in Miyake Y (ed): Electrodiagnosis of Retinal Diseases. Tokyo, Springer, 2006, pp 181–182.
  8. Zhang Y, Cho CH, Atchaneeyasakul LO, McFarland T, Appukuttan B, Stout JT: Activation of the mitochondrial apoptotic pathway in a rat model of central retinal artery occlusion. Invest Ophthalmol Vis Sci 2005;46:2133–2139.
  9. Viswanathan S, Frishman LJ, Robson JG, Harwerth RS, Smith EL 3rd: The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma. Invest Ophthalmol Vis Sci 1999;40:1124–1136.
  10. Rangaswamy NV, Frishman LJ, Dorotheo EU, Schiffman JS, Bahrani HM, Tang RA: Photopic ERGs in patients with optic neuropathies: comparison with primate ERGs after pharmacologic blockade of inner retina. Invest Ophthalmol Vis Sci 2004;45:3827–3837.
  11. Machida S, Gotoh Y, Tanaka M, Tazawa Y: Predominant loss of the photopic negative response in central retinal artery occlusion. Am J Ophthalmol 2004;137:938–940.
  12. Chen H, Wu D, Huang S, Yan H: The photopic negative response of the flash electroretinogram in retinal vein occlusion. Doc Ophthalmol 2006;113:53–59.
  13. Viswanathan S, Frishman LJ, Robson JG, Walters JW: The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest Ophthalmol Vis Sci 2001;42:514–522.
  14. Miyata K, Nakamura M, Kondo M, Lin J, Ueno S, Miyake Y, Terasaki H: Reduction of oscillatory potentials and photopic negative response in patients with autosomal dominant optic atrophy with OPA1 mutations. Invest Ophthalmol Vis Sci 2007;48:820–824.
  15. Ueno S, Kondo M, Piao CH, Ikenoya K, Miyake Y, Terasaki H: Selective amplitude reduction of the PhNR after macular hole surgery: ganglion cell damage related to ICG-assisted ILM peeling and gas tamponade. Invest Ophthalmol Vis Sci 2006;47:3545–3549.
  16. Nagata N: Studies on the photopic ERG of the human retina. Jpn J Ophthalmol 1963;7:96–124.
  17. Rufiange M, Rousseau S, Dembinska O, Lachapelle P: Cone-dominated ERG luminance-response function: the Photopic Hill revisited. Doc Ophthalmol 2002;104:231–248.
  18. Rosolen SG, Rigaudière F, LeGargasson JF, Chalier C, Rufiange M, Racine J, Joly S, Lachapelle P: Comparing the photopic ERG i-wave in different species. Vet Ophthalmol 2004;7:189–192.
  19. Sieving PA, Murayama K, Naarendorp F: Push-pull model of the primate photopic electroretinogram: a role for hyperpolarizing neurons in shaping the b-wave. Vis Neurosci 1994;11:519–532.
  20. Feghali J, Jin J, Odom JV: Effect of short-term intraocular pressure elevation on the rabbit electroretinogram. Invest Ophthalmol Vis Sci 1991;32:2184–2189.
  21. Johnson M, Drum B, Quigley HA: Pattern-evoked potential and optic nerve fiber loss in monocular laser-induced glaucoma. Invest Ophthalmol Vis Sci 1989;30:897–907.
  22. Matsumoto H, Matsumoto CS, Nagata M, Nakatsuka K: Emergency treatment of simultaneous occlusion of central retinal artery and vein (in Japanese). Jpn J Clin Ophthalmol Rinsho Ganka 2005;59:923–927.
  23. Ueno S, Kondo M, Ueno M, Miyata K, Terasaki H, Miyake Y: Contribution of retinal neurons to d-wave of primate photopic electroretinograms. Vision Res 2006;46:658–664.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 20, 2007
Accepted: March 13, 2008
Published online: July 08, 2009
Issue release date: October 2009

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 1

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: https://www.karger.com/OPH


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