Neuroepidemiology

Original Paper

Frequency and Determinants for Hemorrhagic Transformation of Cerebral Infarction

Terruso V.a · D’Amelio M.a · Di Benedetto N.a · Lupo I.a · Saia V.a · Famoso G.a · Mazzola M.A.a · Aridon P.a · Sarno C.b · Ragonese P.a · Savettieri G.a

Author affiliations

aDipartimento di Neuroscienze Cliniche, Università degli Studi di Palermo, and bDipartimento di Biotecnologie Mediche e Medicina Legale, Palermo, Italy

Keywords: Hemorrhagic transformationIschemic strokeEpidemiologyRisk factors

Related Articles for ""
Neuroepidemiology 2009;33:261–265
https://doi.org/10.1159/000229781

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 01, 2009
Accepted: May 27, 2009
Published online: July 27, 2009
Issue release date: October 2009

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: https://www.karger.com/NED

Abstract

Background: Frequency and associated risk factors for hemorrhagic transformation (HT), a worrying complication of ischemic stroke (IS), are not clearly defined. Our aim was to estimate the overall frequency and risk factors for HT in a hospital-based population. Methods: A retrospective review of medical records of patients discharged from our department during the period 2004–2006 with a diagnosis of anterior IS. Demographic, clinical and hematological information was collected. Uni- and multivariate logistic regression analyses were used to estimate risk for spontaneous HT. Results: We included 240 patients (125 males, 52%), mean age at admission was 72.5 years. HT was observed in 29 patients (12%). At univariate analysis, consciousness impairment at admission (OR 5.6, 95% CI 1.3–28.2), the presence of early CT signs (OR 2.4, 95% CI 1.1–5.3), infarcts of medium-large size (OR 11.3, 95% CI 4.1–30.8), cardioembolic stroke (OR 2.3, 95% CI 1.1–5.2) and low total cholesterol levels (OR 3.3, 95% CI 1.3–8.2) were significantly associated with HT. At multivariate analysis, only infarct size (OR 10.2, 95% CI 3.2–32.1) was still significantly associated with HT. Conclusions: Frequency of HT in our study was 12%. Consistently with previous results, HT was associated with the size of ischemic area. As patients included in our study did not receive thrombolytic therapy, our results are applicable to those patients whom clinicians, working in a hospital setting, usually deal with.

© 2009 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 01, 2009
Accepted: May 27, 2009
Published online: July 27, 2009
Issue release date: October 2009

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: https://www.karger.com/NED

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2009, Vol.33, No. 3

October 2009

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