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Original Paper

Simultaneous Characterization of Oxygen Transport into and through Porcine Skin Exposed to Oxygen-Saturated Water

Atrux-Tallau N.a · Le T.H.B.a · Denis A.b · Padois K.a · Zahouani H.c · Haftek M.a · Falson F.a · Pirot F.a, d

Author affiliations

aLaboratoire de Recherche et Développement de Pharmacie Galénique Industrielle EA 4169, Faculté de Pharmacie, Université de Lyon et bBioderma Laboratoire Dermatologique, Lyon, cLaboratoire de Tribologie et Dynamique des Systèmes, Ecole Centrale de Lyon, Ecully, et dService pharmaceutique, Groupement Hospitalier E. Herriot, Lyon, France

Related Articles for ""

Skin Pharmacol Physiol 2009;22:210–217

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 16, 2009
Accepted: April 14, 2009
Published online: July 31, 2009
Issue release date: September 2009

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Oxygen delivery to the skin is a promising approach for treatment of dermatological diseases (e.g. ischemic wound healing). However, characterization of oxygen transport into and through the skin exposed to oxygen carrier formulations has not been reported. In the present study, we developed an original lab-made static diffusion cell mounted with porcine skin enabling the assessment of oxygen uptake into the skin (i.e., oxygen penetration) and passage through the skin (i.e., oxygen permeation). Oxygen penetration and permeation were recorded by using an optical probe implanted into the skin tissue and a Clark-type electrode plunged into the receptor solution of the diffusion cells. Permeability parameters (i.e., maximal and steady-state flux; permeability coefficient) of oxygen were determined after a 2-hour application of oxygen-saturated water to either the skin surface (exogenous delivery) or the dermis (endogenous delivery). Similar experiments were performed by using intact or stripped skin in order to appreciate the role of the stratum corneum as oxygen barrier. Exogenous delivery of oxygen to skin tissue was found more effective than endogenous delivery through intact and stripped skin. However, exogenous oxygen permeation was found smaller than that determined from endogenous delivery. The upper layers of the skin would constitute a potential oxygen reservoir created by the high solubility of oxygen in epidermal lipids. Therefore, oxygen carrier formulations might significantly improve the oxygen status in the skin for further biological effects.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 16, 2009
Accepted: April 14, 2009
Published online: July 31, 2009
Issue release date: September 2009

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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