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Ultradian Pulsatility of Plasma Glucose and Insulin Secretion Rate: Circadian and Sleep Modulation

Simon C.

Author affiliations

JE 2105, Institut de Physiologie, Strasbourg, France

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Horm Res 1998;49:185–190

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 16, 1998
Issue release date: March 1998

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Insulin release is a complex oscillatory process with rapid pulses (10 min) superimposed on slower circhoral oscillations (50–100 min). The exact mechanism of the circhoral oscillations, which are probably in part the consequence of a negative feedback loop linking glucose and insulin secretion rate, remains unclear. Stimulatory effects of sleep on insulin secretion are achieved by an enhancement of the oscillation amplitude which could be partly mediated by GH. The different patterns observed after acute or chronic shift of sleep suggest however an interaction between sleep influence and circadian rhythmicity, as described for numerous pituitary hormones. The intra-sleep awakenings have a modulatory effect on glucose levels but no systematic relationship exists between glucose or insulin secretion rate oscillations and the REM-NREM sleep cycles. Irrespective of the mechanisms involved, sleep or GH stimulatory effects result from a modulation of the oscillation amplitude rather than of their frequency which is probably an important feature of insulin efficacy.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 16, 1998
Issue release date: March 1998

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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