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Original Paper

Free Access

Erythropoietin Sustains Cognitive Function and Brain Volume after Neonatal Stroke

Gonzalez F.F.a · Abel R.d, e · Almli C.R.d–f · Mu D.b, g · Wendland M.c · Ferriero D.M.a, b

Author affiliations

Departments of aPediatrics, bNeurology and cRadiology, University of California, San Francisco, Calif., dDepartmental Neuropsychobiology Laboratory, eProgram in Occupational Therapy, and fDepartment of Neurology, Washington University School of Medicine, St. Louis, Mo., USA; gDepartment of Pediatrics, West China Second Hospital, Sichuan University, Chengdu, China

Corresponding Author

Fernando F. Gonzalez, MD

Neonatal Brain Disorders Laboratory, University of California, San Francisco

521 Parnassus Avenue, C215

San Francisco, CA 94143-0663 (USA)

Tel. +1 415 502 5822, Fax +1 415 502 5821, E-Mail gonzalezf@peds.ucsf.edu

Related Articles for ""

Dev Neurosci 2009;31:403–411

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Neonatal stroke leads to mortality and severe morbidity, but there currently is no effective treatment. Erythropoietin (EPO) promotes cytoprotection and neurogenesis in the short term following brain injury; however, long-term cognitive outcomes and optimal dosing regimens have not been clarified. We performed middle cerebral artery occlusion in postnatal day 10 rats, which were treated with either a single dose of EPO (5 U/g, i.p.) immediately upon reperfusion, or 3 doses of EPO (1 U/g, i.p. each) at 0 h, 24 h, and 7 days after injury. At 3 months after injury, rats treated with 3 doses of EPO did not differ from shams in the Morris water maze, and generally performed better than either rats treated with a single dose or vehicle-treated injured rats. These multiple-dose-treated rats also had increases in hemispheric volume and its subregions. These results suggest that additional, later doses of EPO may be required for cell repair, proliferation, and long-term incorporation into neural networks after neonatal brain injury.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 02, 2008
Accepted: December 20, 2008
Published online: August 11, 2009
Issue release date: September 2009

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 1

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

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