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Original Paper

Characterization and Mitogenesis of Feline Lymphocyte Populations

Rojko J.L.a · Hoover E.A.a · Finn B.L.a · Olsen R.G.a-c

Author affiliations

aDepartment of Veterinary Pathobiology; bComprehensive Cancer Center; cDepartment of Microbiology, Ohio State University, Columbus, Ohio, USA

Related Articles for ""

Int Arch Allergy Immunol 1982;68:226–232

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 10, 1981
Published online: July 31, 2009
Issue release date: 1982

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Feline lymphocyte populations from blood, spleen, lymph node, thymus and bone marrow were examined for the following markers: rosette formation with guinea pig erythrocytes (GPE-T cells); surface feline thymocyte antigen (T cells); surface immunoglobulin (B cells); cytoplasmic immunoglobulin (preB cells, plasma cells); receptors for the Fc portion of IgG (FcyR-positive T and B cells), and the third component of complement (CR-positive cells – primarily B cells). The blastogenic responses of feline lymphocytes from peripheral blood, spleen, lymph node (LN), thymus and marrow were investigated using the following mitogens: Escherichia coli lipopolysaccharide (LPS), dextran sulfate (DxS), concanavalin A (conA), phytohemagglutinin (PHA) and pokeweed mitogen (PWM). Feline T lymphocytes identified by rosette formation with GPE and surface thymocyte antigen were present in thymus, spleen, LN, blood and, rarely, in marrow. T cell subsets, but not B cell subsets, were differentiated according to mitogen activation. Cells responding to PHA were immature, nonrecirculating cells, which were most strongly activated in thymus [stimulation index (SI = 12)], lymph node(SI = 11) and spleen (SI = 6). PWM-responsive cells were relatively mature, recirculating lymphocytes of widespread distribution and blastogenesis was greater in spleen (SI = 36) and LN (SI = 29), followed by thymus (SI = 23) and blood (SI = 15). Con A was a potent mitogen for cells of spleen (SI = 113), blood (SI = 80) and LN (SI = 77), but not thymus (SI = 7), suggesting that the con-A-inducible cell was a mature, recirculating, postthymic cell. Optimal mitogenic response to the B cell mitogen, LPS, was dependent upon increased cell concentrations (3 × 105 versus 1 × 105 per microtiter well) and increased incubation time (5 days versus 3 days). Surface IgG- and IgM-bearing lymphocytes and CR-bearing cells from spleen and blood were stimulated preferentially. DxS was moderately mitogenic for CR-bearing lymphocytes in spleen (SI=4), LN (SI=3) and blood (SI = 3), but not marrow (SI= 1).

© 1982 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 10, 1981
Published online: July 31, 2009
Issue release date: 1982

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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