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Original Paper

LNGFR Induction During Osteogenesis of Human Jaw Periosteum-derived Cells

Alexander D.1 · Schäfer F.1 · Munz A.1 · Friedrich B.2 · Klein C.3 · Hoffmann J.1 · Bühring H.-J.4 · Reinert S.1

Author affiliations

1Department of Oral and Maxillofacial Surgery, University Hospital Tübingen,2Department of Internal Medicine IV, University Hospital Tübingen,3Department of Conservative Dentistry, University Hospital Tübingen,4Department of Internal Medicine II, University Hospital Tübingen

Corresponding Author

Dr. Dorothea Alexander, PhD

Oral and Maxillofacial Surgery, University Hospital Tübingen

Osianderstr. 2-8, 72076 Tübingen (Germany)

Tel. +49-7071-2982418, Fax: +49-7071-294365

E-Mail dorothea.alexander@med.uni-tuebingen.de

Related Articles for ""

Cell Physiol Biochem 2009;24:283–290

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Isolated jaw periosteum-derived cells (JPCs) comprise a morphologically heterogeneous population. There are no known specific surface markers that are able to distinguish between progenitors and cells of other tissue types. The aim of our study was to identify differentiation markers as predictors of JPC mineralization capacity. JPCs underwent osteogenic differentiation after cultivation in osteogenic medium containing known activators. By FACS analysis, we found the low affinity nerve growth factor receptor (LNGFR–CD271) to be induced during the first five days of osteogenesis and that it was expressed at higher levels in mineralizing JPCs (mJPCs) in comparison to non-mineralizing JPCs (nmJPCs). Similar results were obtained by semi-quantitative immunohistochemical stainings and western blot analyses. Quantitative real-time PCR results showed significantly higher LNGFR and alkaline phosphatase transcript levels in mJPCs compared to nmJPCs. LNGFR is a differentiation marker that distinguishes between mineralizing JPCs and non-mineralizing JPCs during the first phase of osteogenesis and can therefore be considered an early surface marker of osteogenic capacity in vitro.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: June 02, 2009
Published online: August 03, 2009
Issue release date: August 2009

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

For additional information: https://www.karger.com/CPB

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