Special Topic Section: Epigenomics in Psychiatry Editor: T. Kinoshita Review
Epigenetic Profiling in Schizophrenia and Major Mental DisordersIwamoto K. · Kato T.
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan
Laboratory for Molecular Dynamics of Mental Disorders
RIKEN Brain Science Institute
2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
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Epigenetic alterations such as DNA methylation and histone modifications are important in the etiology or pathophysiology of mental disorders. Here, we review recent studies on the relationship between DNA methylation and major mental disorders. We will focus on the role of DNA methylation in postmitotic neurons, intra- and interindividual variations in DNA methylation, the possible involvement of methionine metabolism pathways, and candidate and genome-wide DNA methylation as they relate to mental disorders.
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