The Role of Genetics in Delirium in the Elderly Patientvan Munster B.C.a, b · de Rooij S.E.b · Korevaar J.C.a
aDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, and bDepartment of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
B.C. van Munster
Department of Clinical Epidemiology, Biostatistics and Bioinformatics
Room J1B-207-1, Academic Medical Centre, University of Amsterdam, PO Box 22660
NL–1100 DD Amsterdam (The Netherlands)
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Delirium is an important neuropsychiatric syndrome in the elderly that is associated with an increase in mortality, impaired physical and cognitive recovery, and increased healthcare costs. Two important gaps in daily practice with delirium are the pathophysiological obscurity and the low recognition rates. Genetics offers the possibility to contribute knowledge to both of these gaps with its unique and diverse techniques. However, genetic studies in delirium have been scarce until recently, due to the nature of the diagnosis, the etiology of the syndrome, and the pitfalls inherent in the design of genetic studies. This review describes the barriers of this field of research and the implications for our current knowledge of delirium.
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