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Original Paper

Hepatitis B-Associated Acute Liver Failure: Immediate Treatment with Entecavir Inhibits Hepatitis B Virus Replication and Potentially Its Sequelae

Jochum C.a · Gieseler R.K.a, d · Gawlista I.a · Fiedler A.b · Manka P.a · Saner F.H.c · Roggendorf M.b · Gerken G.a · Canbay A.a

Author affiliations

aDivision of Gastroenterology and Hepatology, bInstitute of Virology, and cDepartment of General and Transplantation Surgery, University Hospital Essen, Essen, dDivision of Research and Development, Rodos BioTarget, Hannover, Germany

Related Articles for ""

Digestion 2009;80:235–240

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 25, 2009
Accepted: August 15, 2009
Published online: October 15, 2009
Issue release date: December 2009

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Background: Acute hepatitis B virus (HBV) infection is followed by high viral replication rates leading to hepatocyte death and ultimately, in some cases, to acute liver failure (ALF) necessitating liver transplantation. Thus, the objective of treating HBV-induced ALF is to eliminate or significantly suppress HBV replication. Methods/Results: This prospective study (02/2008–02/2009) included 6 patients (1 female and 5 males, median age 35.5 years). HBV DNA and hepatitis B surface antigen (HBsAg) levels were detected, and hepatocyte death was quantified in patients’ sera by (a) M65 ELISA and (b) M30 ELISA. All patients received entecavir treatment at 1 mg daily within 1–18 days after admission. Upon treatment, pathologic parameters rapidly decreased and returned to normal values or trace amounts (HBV DNA) within 3 months in all of the cases. A seroconversion to anti-HBsAg was achieved in 5 out of 6 patients; one patient with late onset of treatment did not seroconvert. M65 and the difference of M65-M30 as a marker for cell necrosis dropped significantly within 1 week of treatment. Conclusion: This preliminary series of 6 patients reveals that immediate treatment of HBV-induced ALF with entecavir is well tolerated and beneficially affects the course of the disease.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 25, 2009
Accepted: August 15, 2009
Published online: October 15, 2009
Issue release date: December 2009

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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