International Archives of Allergy and Immunology

Pathogenesis: Cellular Effectors and Regulators of Allergic Reactions

The Interaction of Cytokmes with Human Basophils and Mast Cells

Schroeder J.T. · Kagey-Sobotka A. · MacGlashan D.W. · Lichtenstein L.M.

Author affiliations

Johns Hopkins Asthma and Allergy Center, Department of Medicine, Division of Clinical Immunology, Baltimore, Md., USA

Related Articles for ""

Int Arch Allergy Immunol 1995;107:79–81

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Article / Publication Details

First-Page Preview
Abstract of Pathogenesis: Cellular Effectors and Regulators of Allergic Reactions

Published online: September 04, 2009
Issue release date: 1995

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Human mast cells and basophils participate in allergic inflammation by releasing preformed and newly synthesized mediators upon cross-linking of cell surface IgE/receptor complexes with specific antigen. It is becoming increasingly apparent, however, that the basophil response is up-regulated by a far greater number of cytokines than is the mast cell, making the basophil more sensitive to products that are commonly generated during immune reactions. As a result, basophils may have a greater role in the chronic allergic inflammation that characterizes diseases such as asthma. This belief is supported further by the fact that the basophil has recently been shown to generate interleukin-4, and possibly other cytokines, indicating a role for this cell in directing the immune response of other cell participating in allergic lesions.

© 1995 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Pathogenesis: Cellular Effectors and Regulators of Allergic Reactions

Published online: September 04, 2009
Issue release date: 1995

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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