International Archives of Allergy and Immunology

Development and Function of Effector Cells

The Role of c-Kit and Its Ligand, Stem Cell Factor, in Mast Cell Apoptosis

Mekori Y.A.a · Oh C.K.b · Metcalfe D.D.b

Author affiliations

aAllergy-Clinical Immunology Unit, Department of Medicine, Meir General Hospital and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; bAllergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USA

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Int Arch Allergy Immunol 1995;107:136–138

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Article / Publication Details

First-Page Preview
Abstract of Development and Function of Effector Cells

Published online: September 04, 2009
Issue release date: 1995

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

The regulation of tissue mast cell number depends both on the rate of production of mast cell precursors and the length of survival of mature mast cells within tissues. Once mast cell precursors target to tissues, their survival may largely be dependent upon the local production of stem cell factor (SCF). Withdrawal of interleukin (IL)-3 results in mast cell apoptosis. The apoptotic changes following IL-3 deprivation are prevented by the addition of SCF which exerts its rescue effect upon interaction with its c-Kit tyrosine kinase receptor. Mast cells undergo apoptosis on withdrawal of IL-3 coincident with a decrease in endogenous bcl-2 mRNA; however, SCF does not induce expression of bcl-2when added to these cells. When overexpressed, bcl-2prolongs survival of bcl-2-transfected mast cells following IL-3 deprivation. Transforming growth factor-β was found to specifically prevent this SCF-mediated rescue from apoptosis, probably by down-regulating the expression of c-Kit. Thus, microenvironmental factors play an important role in regulating mast cell numbers by effecting survival in the periphery.

© 1995 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Development and Function of Effector Cells

Published online: September 04, 2009
Issue release date: 1995

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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