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Pathogenesis and Management

Study of Liver Function in Infants with Atopic Dermatitis Using the 13C-Methacetin Breath Test

Iikura Y.a · Iwasaki A.a · Tsubaki T.a · Akasawa A.a · Onda T.a · Katsunuma T.a · Miura K.a · Ebisawa M.a · Saito H.a · Koya N.b · Kajiwara M.c

Author affiliations

aDepartment of Allergy and Immunology, National Children’s Hospital Research Center, National Children’s Hospital, Tokyo, bDepartment of Paediatrics, Toho Sakura University School of Medicine, Chiba, and cDepartment of Drug Chemistry, Meiji Pharmaceutical College, Tokyo, Japan

Related Articles for ""

Int Arch Allergy Immunol 1995;107:189–193

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Article / Publication Details

First-Page Preview
Abstract of Pathogenesis and Management

Published online: September 04, 2009
Issue release date: 1995

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Serum glutamic-oxaloacetic transaminase (GOT) levels were determined in 214 infants (133 males and 81 females) with atopic dermatitis during their first visit to the Department of Allergy, National Children’s Hospital, Tokyo, Japan. Compared with the normal hospital range, their levels were found to be significantly higher, a tendancy which was more conspicuous in lower age groups. We carried out a 13C-methacetin breath test (MBT), administering the stable-isotope-labeled compound to 11 children with higher serum GOT values and 5 within the normal range to investigate hepatic metablism of methacetin in infants with atopic dermatitis. 13C-methacetin was given orally, and the 13CO2 level in the breath was determined immediately before and after administration, by mass spectrometry. Compared to the normal controls, the atopic infants demonstrated significantly lower 13CO2 peak excretion and delayed peak time. The clearance rate of 13CO2 was also decreased. These results suggest some relationship between atopic dermatitis and liver function in infants.

© 1995 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Pathogenesis and Management

Published online: September 04, 2009
Issue release date: 1995

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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