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Original Paper

Allergic Sensitization to Native and Heated Celery Root in Pollen-Sensitive Patients Investigated by Skin Test and IgE Binding

Jankiewicz A.a · Aulepp H.b · Baltes W.a · Bögl K.W.c · Dehne L.I.c · Zuberbier T.d · Vieths S.e

Author affiliations

aInstitute of Food Chemistry, Technische Universität Berlin, and bDepartment of Dermatology and Allergology, Borkum Riff Hospital, Borkum, and cFederal Institute for Health Protection of Consumers and Veterinary Medicine, Berlin, and dDepartment of Dermatology, Virchow-Klinikum, Humboldt-Universität zu Berlin, and eDepartment of Allergology, Paul Ehrlich Institute, Langen, Germany

Related Articles for ""

Int Arch Allergy Immunol 1996;111:268–278

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 23, 1996
Accepted: May 28, 1996
Published online: September 04, 2009
Issue release date: 1996

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

The rates of sensitization and allergy to four birch pollen related plant foods were investigated in a group of 167 patients who were sensitive to at least one kind of pollen and one particular food. Sensitivity was concluded from a positive skin prick test or the determination of specific IgE, whereas allergy was based on anamnestic data. The positivity rates for sensitization and allergy, respectively, were: apple, 93 and 84%; hazelnut, 90 and 78%; celery, 70 and 14%; carrot, 60 and 37%. Comparative testing by skin prick test and enzyme allergosorbent test (EAST) with extract from native and microwaved (750 W, 30 min, 100oC) celery root was performed on 46 of these patients. At least one positive test result (either prick test or EAST) was obtained for native celery in 36/46 (78%) and for heated celery in 20/46 (43%) of these patients. Although the concordance between the EAST and the skin test was very low, extended control experiments of both test procedures revealed no evidence for nonspecificity. Immunoblot analyses of extract from native celery and sera of 60 patients with a positive EAST (class ≥ 2, ≥ 0.7 U/ml) for celery resulted in the following rates of IgE binding to known cross-reactive celery allergens: Api g 1:33%, celery profilin: 17%; multiple bands most probably due to carbohydrate epitopes: 32%. The rate of binding to other allergens was below 10%. Since these three important structures are also present in birch pollen, no allergen could be identified as a candidate to mediate an exclusive celery/mugwort association. Investigation of extract from native and heated celery by immunoblotting pointed to a high lability of Api g 1, whereas profilin and carbohydrate epitopes appeared to be more resistant to heat. It has been concluded that sensitization to celery in German patients is without clinical significance in the majority of cases, in contrast to other birch-pollen-related plant foods such as apple and hazelnut. For the particular kind of extract used, neither the EAST nor the skin test alone represents an appropriate diagnostic method for testing sensitization to celery.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 23, 1996
Accepted: May 28, 1996
Published online: September 04, 2009
Issue release date: 1996

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
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