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Original Paper

Comparison of the Effects of Low Intra-Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits

Nesek-Adam V.a · Vnuk D.d · Rašić Ž.b · Rumenjak V.c · Kos J.d · Krstonijević Z.b

Author affiliations

aDepartment of Anesthesiology, Resuscitation and Intensive Care, bUniversity Department of Surgery, and cDepartment of Medical Laboratory Diagnosis, Sveti Duh General Hospital, and dDepartment of Surgery, Orthopedics and Ophthalmology, School of Veterinary Medicine, University of Zagreb, Zagreb, Croatia

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Eur Surg Res 2009;43:330–337

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 11, 2009
Accepted: June 04, 2009
Published online: September 16, 2009
Issue release date: November 2009

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Abstract

Background: The aim of this study was to investigate the effect of low-pressure pneumoperitoneum and pentoxifylline, a methylxanthine derivative, in the prevention of injury caused by free oxygen radicals generated during CO2 pneumoperitoneum. Methods: Twenty-eight rabbits were allocated randomly to 4 groups. Control group rabbits (group 1) were subjected to anesthesia for 60 min; group 2 and 3 animals were subjected to a CO2 pneumoperitoneum (15 or 7 mm Hg); and group 4 rabbits received 50 mg/kg pentoxifylline, followed by a 15-mm-Hg pneumoperitoneum. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), lipid hydroperoxide, glutathione reductase and total antioxidant status were measured. Results: Compared with group 1, a significant increase in lipid hydroperoxide levels at the end of the pneumoperitoneum and 30 min after deflation and a significant decrease in total antioxidant status 24 h after deflation were recorded in group 2. In addition, a significant increase was observed in ALT, AST and LDH levels. These changes were attenuated by low-pressure pneumoperitoneum, whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. Conclusion: Low-pressure pneumoperitoneum could attenuate ischemia/reperfusion injury induced by CO2 pneumoperitoneum in a rabbit model whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. Pentoxifylline did not prevent the development of oxidative stress.

© 2009 S. Karger AG, Basel


References

  1. Eleftheriadis E, Kotzampassi K, Botsios D, Tzartinoglou E, Farmakis H, Dadoukis J: Splanchnic ischemia during laparoscopic cholecystectomy. Surg Endosc 1996;10:324–326.
  2. Diebel LN, Wilson RF, Dulchavsky SA, Saxe J: Effects of increased intra-abdominal pressure on hepatic arterial, portal venous, and hepatic microcirculatory blood flow. J Trauma 1992;33:279–282.
  3. Rasmussen IB, Berggren U, Arvidsson D, Ljungdahl M, Haglund U: Effects of pneumoperitoneum on splanchnic hemodynamics: an experimental study in pigs. Eur J Surg 1995;161:819–826.
  4. Eleftheriadis E, Kotzampassi K, Papanotas K, Heliadis N, Sarris K: Gut ischemia, oxidative stress and bacterial translocation in elevated abdominal pressure in rats. World J Surg 1996;20:11–16.
  5. Seven R, Seven A, Erbil Y, Mercan S, Burcak G: Lipid peroxidation and antioxidant state after laparoscopic and open cholecystectomy. Eur J Surg 1999;165:871–874.
  6. Sare M, Yilmaz I, Hamamci D, Birincioglu M, Özmen M, Yesilada Ö: The effect of carbon dioxide pneumoperitoneum on free radicals. Surg Endosc 2000;14:649–652.
  7. Polat C, Yilmaz S, Serteser M, Koken T, Kahraman A, Dilek ON: The effect of different intra-abdominal pressure on lipid peroxidation and protein oxidation status during laparoscopic cholecystectomy. Surg Endosc 2003;17:1719–1722.
  8. Yilmaz S, Ates E, Polat C, Koken T, Tokyol C, Akbulut G, Gokce O: Ischemic preconditioning decreases laparoscopy-induced oxidative stress in small intestine. Hepatogastroenterology 2003;50:979–982.
  9. Ward A, Clissold SP: Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 1987;34:50–97.
  10. Muller R, Lehrach F: Haemorheological role of platelet aggregation and hypercoagulability in microcirculation: therapeutical approach with pentoxifylline. Pharmaterapeutica 1980;2:372–379.
  11. Steeb GD, Wilson MA, Garrison RN: Pentoxifyilline preserves small-intestine microvascular blood flow during bacteriemia. Surgery 1992;112:756–763.
  12. Waxman K, Clark L, Soliman M: Pentoxifylline in resuscitation of experimental hemorrhagic shock. Crit Care Med 1991;19:728–731.
  13. Fabia R, Travis DL, Levy MF, Husberg BS, Goldstein RM, Klintmalm GB: Effect of pentoxifylline on hepatic ischemia and reperfusion injury. Surgery 1997;121:520–525.
  14. Flynn WJ, Cryer HG, Garrison RN: Pentoxifylline restores intestinal microvascular blood flow during resuscitated hemorrhagic shock. Surgery 1991;110:350–356.
  15. Morino M, Giraudo G, Festa V: Alteration in hepatic function during laparoscopic surgery. An experimental clinical study. Surg Endosc 1998;12:968–972.
  16. Nesek-Adam V, Rašić Ž, Kos J, Vnuk D: Aminotransferases after experimental pneumoperitoneum in dogs. Acta Anaesthesiol Scand 2004;48:862–866.
  17. Bickel A, Weiar A, Eitan A: Evaluation of liver enzymes following elective laparoscopic cholecystectomy: are they really elevated? J Gastrointest Surg 2008;12:1418–1421.
  18. Cevrioglu AS, Yilmaz S, Koken T, Tokyol C, Yilmazer M, Fenkci IV: Comparison of the effects of low intra-abdominal pressure and ischaemic preconditioning on the generation of oxidative stress markers and inflammatory cytokines during laparoscopy in rats. Hum Reprod 2004;19:2144–2151.
  19. Yilmaz S, Polat C, Kahraman A, Koken T, Arikan Y, Dilek ON, Gokce O: The comparison of the oxidative stress effects of different gases and intra-abdominal pressures in an experimental rat model. J Laparoendosc Adv Surg Tech A 2004;14:165–168.
  20. Schmeding M, Neumann UP, Boas-Knoop S, Spinelli A, Neuhaus P: Erythropoietin reduces ischemia-reperfusion injury in the rat liver. Eur Surg Res 2007;39:189–197.
  21. Rhoden E, Pereira-Lima L, Lucas M, Mauri M, Rhoden C, Pereira-Lima JC, Zettler C, Petteffi L, Belló-Klein A: The effects of allopurinol in hepatic ischemia and reperfusion: experimental study in rats. Eur Surg Res 2000;32:215–222.
  22. Zhang WH, Li JY, Zhou Y: Melatonin abates liver ischemia/reperfusion injury by improving the balance between nitric oxide and endothelin. Hepatobiliary Pancreat Dis Int 2006;5:574–579.
    External Resources
  23. Liu Z, Xu Z, Shen W, Li Y, Zhang W, Ye X: Effect of pharmacological preconditioning with tetrandrine on subsequent ischemia/reperfusion injury in rat liver. Word J Surg 2004;28:620–624.
  24. Müller JM, Vollmar B, Menger MD: Pentoxifylline reduces venular leukocyte adherence (‘reflow paradox’) but not microvascular ‘no reflow’ in hepatic ischemia/reperfusion. J Surg Res 1997;71:1–6.
  25. Ciuffetti G, Mercuri M, Ott C, Lombardini R, Paltriccia R, Lupattelli G: Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease. Results of a double-blind placebo-controlled study. Eur J Clin Pharmacol 1991;41:511–515.
  26. Aslan A, Karagüzel G, Celik M, Uysal N, Yücel G, Melikoğlu M: Pentoxifylline contributes to the hepatic cytoprotective process in rats undergoing hepatic ischemia and reperfusion injury. Eur Surg Res 2001;33:285–290.
  27. Peng XX, Currin RT, Thurman RG, Lemasters JJ: Protection by pentoxifylline against normothermic liver ischemia/reperfusion in rat. Transplantation 1995;59:1537–1541.
  28. Yildirim S, Tok H, Köksal H, Erdem L, Baykan A: Allopurinol plus pentoxifylline in hepatic ischaemia reperfusion injury. Asian J Surg 2002;25:149–153.
    External Resources
  29. Dinckan A, Sahin E, Ogus M, Emek K, Gumuslu: The effect of pentoxifylline on oxidative stress in CO2 pneumoperitoneum. Surg Endosc DOI: 10.1007/s00464–008–9856–5
    External Resources
  30. Li C, Jackson RM: Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol 2002;282:C227–C241.
  31. Portakal O, Inal-Erden M: Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia reperfusion injury. Clin Biochem 1999;32:461–466.
  32. Kaye AD, Ibrahim IN, Kadowitz PJ, Nossman BD: Analysis of responses to pentoxifylline in the pulmonary vascular bed of the cat. Crit Care Med 1996:24;263–267.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 11, 2009
Accepted: June 04, 2009
Published online: September 16, 2009
Issue release date: November 2009

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR


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