Chemotherapy
Experimental Chemotherapy
Relation of Arginine-Lysine Antagonism to Herpes simplex Growth in Tissue CultureGriffith R.S. · DeLong D.C. · Nelson J.D.Lilly Laboratory for Clinical Research and Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Ind., USA
Keywords: Herpes simplexArginine-lysine antagonism |
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Article / Publication Details
Published online: September 08, 2009
Issue release date: 1981
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
Abstract
In the studies conducted, arginine deficiency suppressed herpes simplex virus replication in tissue culture. Lysine, an analog of arginine, as an antimetabolite, antagonized the viral growth-promoting action of arginine. The in vitro data may be the basis for the observation that patients prone to herpetic lesions and other related viral infections, particularly during periods of stress, should abstain from arginine excess and may also require supplemental lysine in their diet.
© 1981 S. Karger AG, Basel
Article / Publication Details
Published online: September 08, 2009
Issue release date: 1981
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)
For additional information: https://www.karger.com/CHE
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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